GlpBio

Sec61-IN-1

目录号: GC64840纯度: >98.00%
Sec61-IN-1是有效的Sec61抑制剂。
Sec61-IN-1
Cas No.: 2484865-42-9
规格价格库存数量操作
1mg¥1,328.00现货
1
5 mg¥2,960.00现货
1
10 mg¥4,444.00现货
1
10mM (in 1mL DMSO)¥2,803.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Sec61-IN-1 is an effective Sec61 inhibitor (Patent WO2020176863A1, compound A317).[1].

Sec61-IN-1 exhibits an EC50 of 2543nM after 48-hour treatment on NCI-H929 cells[1].

References:
[1]National Center for Biotechnology Information (2025). PubChem Patent Summary for WO-2020176863-A1, Thiazole derivatives as protein secretion inhibitors. Retrieved March 1, 2025 from https://pubchem.ncbi.nlm.nih.gov/patent/WO-2020176863-A1.

Sec61-IN-1是有效的Sec61抑制剂[1]。

Sec61-IN-1在 NCI-H929细胞上处理48小时测得的EC50为 2543nM[1]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

NCI-H929 cell

Preparation Method

NCI-H929 cells were resuspended in RPMI 1640 media supplemented with 10% fetal bovine serum, 2mM Glutamine, and 1x Penicillin/Streptmycin and plated in 384-well tissue culture plates and treated with Sec61-IN-1 dilutions in DMSO/media. Plates were incubated at 37℃, 5% CO2 for 48 hours. After 48 hours, Celltiter-Glo was added to each well and luciferase signal was quantified for cell viability determination.

Reaction Conditions

48h

Applications

EC50=2543nM

References:
[1]National Center for Biotechnology Information (2025). PubChem Patent Summary for WO-2020176863-A1, Thiazole derivatives as protein secretion inhibitors. Retrieved March 1, 2025 from https://pubchem.ncbi.nlm.nih.gov/patent/WO-2020176863-A1.

产品文档 Product Documents

Purity:>98.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
2484865-42-9
分子式
C23H22N6OS
分子量
430.53 g/mol
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol