关于 "Aldehyde dehydrogenase" 的结果61+ 个结果

Ac-LVF-CHO has been shown to act as a potent HIV protease inhibitor (IC??= 0.9 µM) and to have increased activity against cathepsin D and pepsin (IC??= 37 µM and 100 µM).

Boc-NFP-aldehyde inhibits prolyl endopeptidases.

Pyruvicaldehyde常被用作有机合成中的一种试剂，一种调味剂以及在鞣革中的应用。

Z-PP-CHO dimethylacetal was shown to be a potent inhibitor of prolyl endopeptidase (PEP), a cytoplasmic serine endoprotease (IC??= 120 nM). It is suggested that PEP inhibitors could be useful for the treatment of cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.

The reversible cathepsin B inhibitor GFG-aldehyde semicarbazone has been used in the purification of the cathepsin B-like proteinase Sj31 from Schistosoma japonicum by affinity chromatography and for isolating falcipains from Plasmodium species.

A mixture of a derivative and an adduct of prednisone

Ac-Tyr-Val-Lys-Asp-aldehyde 是 caspase-1 抑制剂，能够用于慢性疾病相关贫血、化疗诱导贫血和钻石黑扇贫血的疾病研究。

The peptide aldehyde SIB1281 inhibited the formation of β- and γ-secretase derived amyloid β-protein (Aβ) with IC?? = 1.8 µM and stimulated the formation of α-secretase derived soluble amyloid precursor protein (sα) with an EC?? of 250 nM.

Z-LLY-α-keto aldehyde (peptidyl glyoxal), previously shown to be an excellent inhibitor of the serine and cysteine proteases, was found to be an excellent inhibitor of the chymotryptic-like activity of proteasome exhibiting a Ki value of approximately 3.0 nM. Such inhibitor might be valuable in the characterization of the role of proteasome in normal and aberrant pathways of protein catabolism in the cell.

The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly induced the accumulation of the 32 kD precursor.

Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM).

The peptide aldehyde Ac-ESMD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 25-28). In a concentration range of 2.5 - 5 µM, it blocked the formation of the p17 subunit and concomitantly induced the accumulation of the p20 peptide.

Ac-LEHD-CHO, reversible inhibitor of caspase-9.