关于 "Aldehyde Dehydrogenase (ALDH)" 的结果63+ 个结果
- Z-Leu-Leu-Tyr-α-keto aldehydeCAS: 204649-66-1
Z-LLY-α-keto aldehyde (peptidyl glyoxal), previously shown to be an excellent inhibitor of the serine and cysteine proteases, was found to be an excellent inhibitor of the chymotryptic-like activity of proteasome exhibiting a Ki value of approximately 3.0 nM. Such inhibitor might be valuable in the characterization of the role of proteasome in normal and aberrant pathways of protein catabolism in the cell.
- Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)CAS: 191338-86-0
The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly induced the accumulation of the 32 kD precursor.
- Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid)CAS: 184179-08-6
Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM).
- Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)CAS: 191338-87-1
The peptide aldehyde Ac-ESMD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 25-28). In a concentration range of 2.5 - 5 µM, it blocked the formation of the p17 subunit and concomitantly induced the accumulation of the p20 peptide.
- Ac-Leu-Glu-His-Asp-aldehyde (pseudo acid)CAS: 319494-38-7
Ac-LEHD-CHO, reversible inhibitor of caspase-9.
- Ac-Leu-Glu-Val-Asp-aldehyde (pseudo acid)CAS: 402832-01-3
Ac-LEVD-CHO, inhibitor of caspase-4 (ICH-2).
- Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)CAS: 189275-71-6
Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
- Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid)CAS: 319494-39-8
AC-VEID-CHO, a specific inhibitor of caspase-6 (Mch2).
- Biotinyl-Asp-Glu-Val-Asp-aldehyde (pseudo acid)CAS: 178603-73-1
这种生物素化的 apopain 抑制剂已成功用于 caspase-3（apopain）的亲和纯化 - 在链霉亲和素-琼脂糖柱上，caspase-3 是一种裂解聚（ADP-核糖）聚合酶 (PARP) 的酶。 Biotinyl-DEVD-CHO 显示出与 N-乙酰化类似物抑制剂 (H-2496) 相当的抑制活性（IC50 \u003d 0.2 nM）。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GA23855 | Z-Leu-Leu-Tyr-α-keto aldehyde | 204649-66-1 | - | ||
Z-LLY-α-keto aldehyde (peptidyl glyoxal), previously shown to be an excellent inhibitor of the serine and cysteine proteases, was found to be an excellent inhibitor of the chymotryptic-like activity of proteasome exhibiting a Ki value of approximately 3.0 nM. Such inhibitor might be valuable in the characterization of the role of proteasome in normal and aberrant pathways of protein catabolism in the cell. | |||||
| GA20581 | Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid) | 191338-86-0 | - | ||
The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly induced the accumulation of the 32 kD precursor. | |||||
| GA20493 | Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid) | 184179-08-6 | - | ||
Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM). | |||||
| GA20565 | Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid) | 191338-87-1 | - | ||
The peptide aldehyde Ac-ESMD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 25-28). In a concentration range of 2.5 - 5 µM, it blocked the formation of the p17 subunit and concomitantly induced the accumulation of the p20 peptide. | |||||
| GA20590 | Ac-Leu-Glu-His-Asp-aldehyde (pseudo acid) | 319494-38-7 | - | ||
Ac-LEHD-CHO, reversible inhibitor of caspase-9. | |||||
| GA20593 | Ac-Leu-Glu-Val-Asp-aldehyde (pseudo acid) | 402832-01-3 | - | ||
Ac-LEVD-CHO, inhibitor of caspase-4 (ICH-2). | |||||
| GA20660 | Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid) | 189275-71-6 | - | ||
Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported. | |||||
| GA20677 | Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid) | 319494-39-8 | - | ||
AC-VEID-CHO, a specific inhibitor of caspase-6 (Mch2). | |||||
| GA20827 | Biotinyl-Asp-Glu-Val-Asp-aldehyde (pseudo acid) | 178603-73-1 | - | ||
这种生物素化的 apopain 抑制剂已成功用于 caspase-3（apopain）的亲和纯化 - 在链霉亲和素-琼脂糖柱上，caspase-3 是一种裂解聚（ADP-核糖）聚合酶 (PARP) 的酶。 Biotinyl-DEVD-CHO 显示出与 N-乙酰化类似物抑制剂 (H-2496) 相当的抑制活性（IC50 \u003d 0.2 nM）。 | |||||
| GA20676 | Ac-Val-Asp-Val-Ala-Asp-aldehyde (pseudo acid) | 194022-51-0 | - | ||
Ac-VDVAD-CHO. | |||||
| GA20627 | Ac-N-Me-Tyr-Val-Ala-Asp-aldehyde (pseudo acid) | 160806-26-8 | - | ||
Inhibited ICE with Ki = 0.12 µM. | |||||
| GC18798 | 11-cis Retinal | 564-87-4 | Ophthalmology | ||
An inverse agonist of opsin | |||||
| GC17293 | PHGDH-inactive | 1914971-16-6 | Dehydrogenase | ||
A negative control for NCT-502 and NCT-503 | |||||
| GC13760 | TC HSD 21 | 330203-01-5 | Others | ||
An inhibitor of 17β-HSD3 | |||||
| GC60763 | DHODH-IN-11 | 1263303-95-2 | Dihydroorotate Dehydrogenase | ||
A derivative of leflunomide | |||||