关于 "Bromodomain" 的结果40+ 个结果
- ACBI1CAS: 2375564-55-7
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
- AZD5153 6-Hydroxy-2-naphthoic acidCAS: 1869912-40-2
AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
- L Moses dihydrochloride
High affinity and selective PCAF bromodomain inhibitor
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC14361 | PFI 3 | 1819363-80-8 | Epigenetic Reader Domain | ||
Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5) | |||||
| GC15375 | PFI-1 (PF-6405761) | 1403764-72-6 | Autophagy | ||
A BET bromodomain inhibitor | |||||
| GC10402 | Bromosporine | 1619994-69-2 | Epigenetic Reader Domain | ||
A non-specific bromodomain inhibitor | |||||
| GC16611 | GW841819X | - | Bromodomain | ||
BET bromodomain inhibitor | |||||
| GC13822 | (-)-JQ1 | 1268524-71-5 | Epigenetic Reader Domain | ||
A selective inhibitor of BET bromodomains | |||||
| GC35227 | ACBI1 | 2375564-55-7 | Other Apoptosis | ||
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. | |||||
| GC35297 | Alobresib | 1637771-14-2 | Epigenetic Reader Domain | ||
A BET bromodomain inhibitor | |||||
| GC35448 | AZD5153 6-Hydroxy-2-naphthoic acid | 1869912-40-2 | Epigenetic Reader Domain | ||
AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes. | |||||
| GC36734 | NI-42 | 1884640-99-6 | Epigenetic Reader Domain | ||
An inhibitor of the BRPF1 bromodomain | |||||
| GC36887 | PF-CBP1 hydrochloride | 2070014-93-4 | Histone Acetyltransferases | ||
An inhibitor of the CBP and p300 bromodomains | |||||
| GC34726 | PROTAC BET-binding moiety 2 | 916493-82-8 | Ligand for Target Protein for PROTAC | ||
PROTACBET-bindingmoiety2是BETbromodomain的抑制剂。 | |||||
| GC50267 | ISOX DUAL | 1962928-22-8 | - | ||
Dual BRD4 and CBP/p300 bromodomain inhibitor | |||||
| GC50340 | TC AC 28 | 1809296-92-1 | Epigenetic Reader Domain | ||
High affinity BET bromodomain ligand | |||||
| GC50395 | L Moses dihydrochloride | - | Epigenetic Reader Domain | ||
High affinity and selective PCAF bromodomain inhibitor | |||||
| GC50542 | TP 238 | 2415263-04-4 | Epigenetic Reader Domain | ||
A chemical probe for the bromodomains of CECR2 and BPTF | |||||
| GC60182 | GSK046 | 2474876-09-8 | Bromodomain | ||
A BD2 bromodomain inhibitor | |||||