关于 "VEGFR" 的结果11 个结果

Motesanib (AMG 706) 是一种有效的 ATP 竞争性 VEGFR1/2/3 抑制剂，IC50 分别为 2 nM/3 nM/6 nM，对 Kit 具有相似的活性，对 VEGFR 的选择性比对 VEGFR 的选择性高约 10 倍PDGFR 和 Ret。

A dual VEGFR and PDGFR family kinase inhibitor

A dual VEGFR and PDGFR family kinase inhibitor

A dual VEGFR and PDGFR family kinase inhibitor

Cabozantinib (XL184,BMS-907351) 是一种新型 MET 和 VEGFR2 抑制剂，可同时抑制转移、血管生成和肿瘤生长。

A dual inhibitor of Kit and VEGFR2

A selective VEGFR2 inhibitor

An inhibitor of VEGFR2 and VEGFR3

Sitravatinib是一种酪氨酸激酶抑制剂（TKI），能够作用于TYRO3、AX和MERTK（TAM）受体、血管内皮生长因子受体（VEGFR）家族、c-Kit 和 c-MET。

Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.

CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.