关于 "Cancer stem cell" 的结果34+ 个结果
筛选:Stem Cell×
- CyclopamineCAS: 4449-51-8
Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。
- PurmorphamineCAS: 483367-10-8
Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。
- GDC-0449 (Vismodegib)CAS: 879085-55-9
GDC-0449 (Vismodegib)是一种具有口服活性和高效选择性的Smoothened（SMO）受体抑制剂，可抑制Hedgehog信号通路，IC 50 值为3.0nM。同时，也可抑制P-gp和ABCG2的活性，IC 50 值分别为3.0μM和1.4μM。
- Bruceine DCAS: 21499-66-1
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC14882 | Salinomycin | 53003-10-4 | Other Apoptosis | ||
A selective cancer stem cell inhibitor | |||||
| GC17339 | ML-243 | 1426576-80-8 | Cancer stem cell | ||
An inhibitor of breast cancer stem cells | |||||
| GC17468 | ML 239 | 1378872-36-6 | Others | ||
An inhibitor of breast cancer stem cells | |||||
| GC14572 | KY 02111 | 1118807-13-8 | iPSC | ||
Induces stem cell differentiation | |||||
| GC10910 | IQ 1 | 331001-62-8 | Wnt/β-catenin | ||
A stem cell pluripotency factor | |||||
| GC12811 | BRD7116 | 329059-55-4 | Others | ||
A selective inhibitor of leukemia stem cells | |||||
| GC10854 | IDE 2 | 1136466-93-7 | Wnt/β-catenin | ||
An inducer of definitive endoderm from embryonic stem cells | |||||
| GC15123 | IDE 1 | 1160927-48-9 | Others | ||
An inducer of definitive endoderm from embryonic stem cells | |||||
| GC12781 | XAV-939 | 284028-89-3 | Wnt/β-catenin | ||
XAV-939 选择性抑制 β-连环蛋白介导的转录。 | |||||
| GC13176 | CP21R7 | 125314-13-8 | GSK-3 | ||
A GSK3β inhibitor used to differentiate stem cells | |||||
| GC13441 | Cyclopamine | 4449-51-8 | Endogenous Metabolite | ||
Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。 | |||||
| GC15064 | Purmorphamine | 483367-10-8 | Autophagy | ||
Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。 | |||||
| GC50703 | Yhhu 3792 | 2097826-24-7 | Notch | ||
Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo | |||||
| GC49027 | Hexamethylene bisacetamide | 3073-59-4 | Cancer stem cell | ||
A tumor cell-differentiating agent | |||||
| GC17534 | GSK343 | 1346704-33-3 | Autophagy | ||
A selective, cell-permeable EZH2 inhibitor | |||||
| GC16454 | IWP-2 | 686770-61-6 | Casein Kinase | ||
IWP-2 是Wnt信号通路中Porcupine 酶的特异性抑制剂,IC50值为 27 nM。 | |||||
| GC17043 | StemRegenin 1 (SR1) | 1227633-49-9 | Aryl Hydrocarbon Receptor | ||
StemRegenin 1 (SR1)是一种强效芳香烃受体（AhR）拮抗剂（IC50 = 127nM）。 | |||||
| GC14847 | Psoralidin | 18642-23-4 | Reactive Oxygen Species | ||
A furanocoumarin with anti-cancer activity | |||||
| GC10493 | GDC-0449 (Vismodegib) | 879085-55-9 | Autophagy | ||
GDC-0449 (Vismodegib)是一种具有口服活性和高效选择性的Smoothened（SMO）受体抑制剂，可抑制Hedgehog信号通路，IC50值为3.0nM。同时，也可抑制P-gp和ABCG2的活性，IC50值分别为3.0μM和1.4μM。 | |||||
| GC11111 | Jervine | 469-59-0 | Smoothened | ||
An inhibitor of the hedgehog signaling pathway | |||||
| GC35559 | Bruceine D | 21499-66-1 | Other Apoptosis | ||
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway. | |||||
| GC16702 | CHIR-99021 (CT99021) | 252917-06-9 | Autophagy | ||
CHIR-99021是最常用的GSK-3β抑制剂，被认为是标准的小分子Wnt激动剂。 | |||||
| GC16789 | GANT 58 | 64048-12-0 | GLI | ||
An inhibitor of Gli transcription | |||||
| GC15256 | JK 184 | 315703-52-7 | Hedgehog | ||
An inhibitor of downstream hedgehog signaling | |||||