关于 "ROS" 的结果41+ 个结果
- Napsagatran hydrate (Ro 46-6240 hydrate)CAS: 159668-20-9
Napsagatran hydrate (Ro 46-6240 hydrate) 是一种新型的特异性凝血酶抑制剂。
- Methyl rosmarinateCAS: 99353-00-1
Methyl rosmarinate 是一种从 Rabdosia serra 中分离得到的非竞争性 tyrosinase 抑制剂，对蘑菇酪氨酸酶作用的 IC50 值为 0.28 mM，也能抑制 a-glucosidase[1]。
- Rosmarinic acid racemateCAS: 537-15-5
Rosmarinic acid racemate是Rosmarinic acid的外消旋体。Rosmarinic acid抑制MAO-A, MAO-B 和COMT酶，IC50分别为50.1, 184.6 和26.7 μM。
- RosamultinCAS: 88515-58-6
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
- Rosuvastatin-d6 (sodium salt)CAS: 2070009-41-3
An internal standard for the quantification of rosuvastatin
- N-desmethyl Rosuvastatin (sodium salt hydrate)
An active metabolite of rosuvastatin
- BalapiravirCAS: 690270-29-2
Balapiravir (Ro 4588161; R1626) 是 HCV (R1479; 4'-Azidocytidine) 的 RNA 依赖性 RNA 聚合酶 (RdRp) 的核苷类似物抑制剂的口服活性前药。
- β-SitostenoneCAS: 1058-61-3
β-Sitostenone 是一种从 Cochlospermum vitifolium 中分离得到的甾醇。β-Sitostenone 可抑制酪氨酸酶 (tyrosinase) 活性，并具有抗黑色素生成和抗肿瘤活性。
- AzvudineCAS: 1011529-10-4
Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
- GalegenimabCAS: 2403683-24-7
Galegenimab (FHTR 2163; RG 6147; RO 7171009)，一种抗 HTRA1 抗体片段。Galegenimab 可用于年龄相关性黄斑变性 (AMD) 研究。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC73225 | ROS-generating agent 1 | 2369030-41-9 | Ferroptosis | ||
ROS-generating agent 1（化合物2c）共价修饰TrxR的Sec-498残基生成ROS。 | |||||
| GC37549 | RO-5963 | 1416663-77-8 | E1/E2/E3 Enzyme | ||
RO-5963 是 p53-MDM2 和 p53-MDMX 互相作用的双抑制剂，IC50 值分别约为 17 nM 和 24 nM。 | |||||
| GC10805 | Ro 32-3555 | 190648-49-8 | MMP | ||
Ro 32-3555 是一种有效的、竞争性的人类胶原酶 1、2 和 3 抑制剂，Kis 分别为 3.0、4.4 和 3.4 nM。 | |||||
| GC33881 | Ro 31-9790 (GI4747) | 145337-55-9 | MMP | ||
Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。 | |||||
| GC34032 | Napsagatran hydrate (Ro 46-6240 hydrate) | 159668-20-9 | Thrombin | ||
Napsagatran hydrate (Ro 46-6240 hydrate) 是一种新型的特异性凝血酶抑制剂。 | |||||
| GC36595 | Methyl rosmarinate | 99353-00-1 | Tyrosinases | ||
Methyl rosmarinate 是一种从 Rabdosia serra 中分离得到的非竞争性 tyrosinase 抑制剂，对蘑菇酪氨酸酶作用的 IC50 值为 0.28 mM，也能抑制 a-glucosidase[1]。 | |||||
| GC37558 | Rosmarinic acid racemate | 537-15-5 | Endogenous Metabolite | ||
Rosmarinic acid racemate是Rosmarinic acid的外消旋体。Rosmarinic acid抑制MAO-A, MAO-B 和COMT酶，IC50分别为50.1, 184.6 和26.7 μM。 | |||||
| GC41380 | N-desmethyl Rosiglitazone | 257892-31-2 | Drug Metabolite | ||
A major metabolite of rosiglitazone | |||||
| GC33426 | Rocaglamide (Rocaglamide A) | 84573-16-0 | NF-κB | ||
Rocaglamide (Rocaglamide A) 是从 Aglaia 属（楝科）中分离出来的。 | |||||
| GC19312 | RO8994 | 1309684-94-3 | E1/E2/E3 Enzyme | ||
An inhibitor of MDM2-p53 interaction | |||||
| GC39068 | Rosamultin | 88515-58-6 | HIV Protease | ||
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis. | |||||
| GC16197 | RO4929097 | 847925-91-1 | Notch | ||
An inhibitor of γ-secretase | |||||
| GC48060 | Rosuvastatin-d6 (sodium salt) | 2070009-41-3 | Acute Phase Reactants | ||
An internal standard for the quantification of rosuvastatin | |||||
| GC47756 | N-desmethyl Rosuvastatin (sodium salt hydrate) | - | Drug Metabolite | ||
An active metabolite of rosuvastatin | |||||
| GC10930 | Balapiravir | 690270-29-2 | HCV | ||
Balapiravir (Ro 4588161; R1626) 是 HCV (R1479; 4'-Azidocytidine) 的 RNA 依赖性 RNA 聚合酶 (RdRp) 的核苷类似物抑制剂的口服活性前药。 | |||||
| GC70185 | β-Sitostenone | 1058-61-3 | Tyrosinases | ||
β-Sitostenone 是一种从 Cochlospermum vitifolium 中分离得到的甾醇。β-Sitostenone 可抑制酪氨酸酶 (tyrosinase) 活性，并具有抗黑色素生成和抗肿瘤活性。 | |||||
| GC25117 | Azvudine | 1011529-10-4 | HCV Protease | ||
Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). | |||||
| GC12339 | Ivermectin | 70288-86-7 | Autophagy | ||
Ivermectin是一种大环内酯类内外抗寄生虫药，对体内和体外寄生虫均有活性。 | |||||
| GC18144 | CTS-1027 | 193022-04-7 | MMP | ||
An inhibitor of MMPs | |||||
| GC12879 | Danoprevir (RG7227) | 850876-88-9 | SARS-CoV | ||
An HCV NS3/4A protease inhibitor | |||||
| GC69145 | Galegenimab | 2403683-24-7 | Ser/Thr Protease | ||
Galegenimab (FHTR 2163; RG 6147; RO 7171009)，一种抗 HTRA1 抗体片段。Galegenimab 可用于年龄相关性黄斑变性 (AMD) 研究。 | |||||
| GC11594 | RG7388 | 1229705-06-9 | E1/E2/E3 Enzyme | ||
RG7388是一种具有口服活性的MDM2（IC50=6nM）拮抗剂，RG7388通过抑制MDM2-p53相互作用来激活p53通路。 | |||||
| GC15335 | Saquinavir | 127779-20-8 | HIV | ||
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂，用于抗逆转录病毒治疗。 | |||||
| GC12859 | Cilazapril | 88768-40-5 | ACE | ||
A prodrug form of cilazaprilat | |||||