关于 "Cytoskeleton & Motor Proteins" 的结果177+ 个结果

This peptide is a specifically designed negative control in studies with Abeta40. It is "scrambled", which means it contains the same amino acids as Abeta40, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-40) does not show a number of phenomena regularly observed with Abeta40 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.

This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.

Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。

For immobilization of Aβ40.

For immobilization of Aβ42.

一种PKC的肽底物

β-Amyloid 22-35 (Amyloid β-Protein (22-35))是一种由14个氨基酸组成的多肽片段，能够自发聚集形成β-折叠结构，并对海马神经元产生显著的细胞毒性作用。

β-Amyloid 29-40 (Amyloid beta-protein(29-40)) 是 Amyloid-β 的一个片段；肽。

Tyrosinase-related Protein 2 (TRP-2) (181-188) 是 TRP2 蛋白的 181-188 序列短肽，是 anti-B16 CTLs 识别 TRP-2 的主要反应表位。Tyrosinase-related Protein 2 (TRP-2) (181-188) 与 MHC I 类 H2-Kb 结合基序一致。

β-Amyloid 1-16 (Amyloid β-Protein (1-16)) 是 ⋲-Amyloid 蛋白片段，参与金属结合。

β-Amyloid 1-28 (Amyloid β-Protein (1-28)) 是 β-Amyloid 蛋白片段，参与金属结合。

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It mimicks the wild-type (JMV2235) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is cleaved by BACE1, BACE2, and cathepsin D.

五肽 Ac-LPFFD-NH? (iAβ5p) 是产品 H-4876 的类似物，具有少量化学修饰，可增强其抗蛋白水解降解的稳定性。 iAβ5p 充当 77777#946;-片断肽并以比已知被大脑选择性吸收的大多数蛋白质和肽更高的速率穿过血脑屏障，因此假设该肽被特异性运输到大脑。 iAβ5p 还报道了两种不同的转基因阿尔茨海默病 (AD) 模型中与淀粉样斑块减少相关的神经元存活显着增加和脑部炎症减少。

This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²?I-labeled APP to heparin (IC??= 10??M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.

Fluorescent dye-labeled Aβ40, excitation at 649 nm, emission at 664 nm. Tide Fluor™ 5WS shows strong fluorescence and excellent photostability.

Fluorescent dye-labeled Aβ40, excitation at 749nm, emission at 775nm. Tide Fluor™ 7WS shows strong fluorescence and excellent photostability.

SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.

This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.

一种能引起脑炎的肽。

A CaMKII inhibitor