关于 "Cytoskeleton & Motor Proteins" 的结果177+ 个结果
- (Met(O₂)³⁵)-Amyloid β-Protein (1-42)CAS: 1802086-69-6
Maiti et al. could show that, in contrast to the sulfoxide of Aβ (1-42), the sulfone was as toxic and aggregated as fast as wild-type Aβ (1-42).
- 5-FAM-Amyloid β-Protein (1-40)CAS: 1678416-08-4
5-FAM-Amyloid β；-Protein (1-40) 是 FAM 荧光标记的 β；-Amyloid (1-40) 肽（&Lambda；ex=492nm 和 &Lambda；em=518nm）。
- 5-TAMRA-Amyloid β-Protein (1-40)CAS: 1802087-81-5
Anderson and Webb could verify using transmission electron microscopy that N-terminal labeling of Aβ40 with TAMRA and other fluorescent dyes does not prevent the formation of protofibrils and amyloid fibrils of various widths.
- Acetyl-Amyloid β-Protein (15-20) amideCAS: 189064-06-0
Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.
- Acetyl-Amyloid β-Protein (1-6) amideCAS: 903883-22-7
Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.
- Amyloid β/A4 Protein Precursor₇₇₀ (667-676)CAS: 252256-37-4
The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.
- Amyloid β/A4 Protein Precursor₇₇₀ (740-770)CAS: 1802086-24-3
Amyloid β/A4 Protein Precursor??? (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.
- Biotinyl-εAhx-Amyloid β-Protein (1-40)CAS: 1802086-72-1
The flexible LC spacer increases the accessibility of the biotin moiety.
- Biotinyl-εAhx-Amyloid β-Protein (1-42)
The flexible LC spacer increases the accessibility of the biotin moiety.
- Activated Protein C (390-404), human TFA
Activated Protein C (390-404), human TFA 是一种维生素 K 依赖的丝氨酸蛋白酶活化蛋白 C (APC) 的多肽片段，可抑制 APC 的抗凝血活性。
Peptides - Calmodulin-Dependent Protein Kinase II 281-309CAS: 116826-37-0
Calmodulin-Dependent Protein Kinase II (281-309) 是钙/钙调素依赖蛋白激酶 II (CaM kinase II) 多肽片段。
Peptides - Human Papillomavirus (HPV) E7 protein 49-57CAS: 151812-18-9
Human Papillomavirus (HPV) E7 protein (49-57) 是 H-2d 限制性人乳头瘤病毒 (HPV) E749-57 表位（即在 E7 蛋白中跨越 49 到 57 个氨基酸残基的短肽）。
Peptides - β-Amyloid Protein Precursor 770 135-155CAS: 315229-44-8
β-Amyloid Protein Precursor 770 (135-155) 是 β 淀粉样前体蛋白的一个亚型 (APP 770) 的多肽片段。APP 770 产生 Aβ40/42。
- (Cys⁴⁷)-HIV-1 tat Protein (47-57)CAS: 627079-23-6
(Cys⁴⁷)-HIV-1 tat 蛋白 (47-57) 具有膜易位功能，可用于衍生磁性药物的表面并大大促进其被靶细胞吸收。
Peptides - Peripheral Myelin Protein P2 (53-78), bovineCAS: 81628-50-4
Peripheral Myelin Protein P2 (53-78), bovine 是源自牛外周髓磷脂 P2 蛋白氨基酸残基 53-78。Peripheral Myelin Protein P2 (53-78), bovine 是一种 T 细胞抗原表位，可在 Lewis 大鼠中诱导实验性自身免疫性神经炎 (EAN)。
Peptides - Tyrosine Protein Kinase JAK 2 Phospho-Tyr8, 9CAS: 247171-44-4
TyrosineProteinKinaseJAK2(Phospho-Tyr8,9)是小鼠JAK2对应的475到491氨基酸序列的多肽。
Peptides - Peripheral Myelin P0 Protein (180-199), mouseCAS: 147450-30-4
PeripheralMyelinP0Protein(180-199),mouse是一种神经原性肽，是鼠类外周神经髓磷脂的纯化成分。
Peptides - (Des-Glu²²)-Amyloid β-Protein (1-42)CAS: 1239313-74-6
The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.
- 5-FAM-Amyloid β-Protein (1-42) (scrambled)
Fluorescent dye-labeled inactive control for H-1368, H-6466, H-8146.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GA20254 | (Met(O₂)³⁵)-Amyloid β-Protein (1-42) | 1802086-69-6 | Amyloid β protein | ||
Maiti et al. could show that, in contrast to the sulfoxide of Aβ (1-42), the sulfone was as toxic and aggregated as fast as wild-type Aβ (1-42). | |||||
| GA20433 | 5-FAM-Amyloid β-Protein (1-40) | 1678416-08-4 | Amyloid β protein | ||
5-FAM-Amyloid β；-Protein (1-40) 是 FAM 荧光标记的 β；-Amyloid (1-40) 肽（&Lambda；ex=492nm 和 &Lambda；em=518nm）。 | |||||
| GA20435 | 5-FAM-Amyloid β-Protein (1-42) | 1802087-78-0 | Amyloid β protein | ||
| GA20440 | 5-TAMRA-Amyloid β-Protein (1-40) | 1802087-81-5 | Amyloid β protein | ||
Anderson and Webb could verify using transmission electron microscopy that N-terminal labeling of Aβ40 with TAMRA and other fluorescent dyes does not prevent the formation of protofibrils and amyloid fibrils of various widths. | |||||
| GA20441 | 5-TAMRA-Amyloid β-Protein (1-42) | 1802087-80-4 | Amyloid β protein | ||
| GA20534 | Acetyl-Amyloid β-Protein (15-20) amide | 189064-06-0 | Amyloid β protein | ||
Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites. | |||||
| GA20535 | Acetyl-Amyloid β-Protein (1-6) amide | 903883-22-7 | Amyloid β protein | ||
Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers. | |||||
| GA21462 | FITC-εAhx-Amyloid β-Protein (1-42) | - | Amyloid β protein | ||
| GA20718 | Amyloid β/A4 Protein Precursor₇₇₀ (667-676) | 252256-37-4 | Amyloid β protein | ||
The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity. | |||||
| GA20719 | Amyloid β/A4 Protein Precursor₇₇₀ (740-770) | 1802086-24-3 | Amyloid β protein | ||
Amyloid β/A4 Protein Precursor??? (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis. | |||||
| GA20854 | Biotinyl-εAhx-Amyloid β-Protein (1-40) | 1802086-72-1 | Amyloid β protein | ||
The flexible LC spacer increases the accessibility of the biotin moiety. | |||||
| GA20855 | Biotinyl-εAhx-Amyloid β-Protein (1-42) | - | Amyloid β protein | ||
The flexible LC spacer increases the accessibility of the biotin moiety. | |||||
| GC35246 | Activated Protein C (390-404), human TFA | - | Peptides | ||
Activated Protein C (390-404), human TFA 是一种维生素 K 依赖的丝氨酸蛋白酶活化蛋白 C (APC) 的多肽片段，可抑制 APC 的抗凝血活性。 | |||||
| GC35595 | Calmodulin-Dependent Protein Kinase II 281-309 | 116826-37-0 | Peptides | ||
Calmodulin-Dependent Protein Kinase II (281-309) 是钙/钙调素依赖蛋白激酶 II (CaM kinase II) 多肽片段。 | |||||
| GC36264 | Human Papillomavirus (HPV) E7 protein 49-57 | 151812-18-9 | Peptides | ||
Human Papillomavirus (HPV) E7 protein (49-57) 是 H-2d 限制性人乳头瘤病毒 (HPV) E749-57 表位（即在 E7 蛋白中跨越 49 到 57 个氨基酸残基的短肽）。 | |||||
| GC37998 | β-Amyloid Protein Precursor 770 135-155 | 315229-44-8 | Amyloid β protein | ||
β-Amyloid Protein Precursor 770 (135-155) 是 β 淀粉样前体蛋白的一个亚型 (APP 770) 的多肽片段。APP 770 产生 Aβ40/42。 | |||||
| GA20052 | (Cys²⁶)-Amyloid β-Protein (1-40) (Dimer) | 1802087-75-7 | Amyloid β protein | ||
Dimer of H-7402. | |||||
| GA20054 | (Cys⁴⁷)-HIV-1 tat Protein (47-57) | 627079-23-6 | Peptides | ||
(Cys⁴⁷)-HIV-1 tat 蛋白 (47-57) 具有膜易位功能，可用于衍生磁性药物的表面并大大促进其被靶细胞吸收。 | |||||
| GC69686 | Peripheral Myelin Protein P2 (53-78), bovine | 81628-50-4 | Peptides | ||
Peripheral Myelin Protein P2 (53-78), bovine 是源自牛外周髓磷脂 P2 蛋白氨基酸残基 53-78。Peripheral Myelin Protein P2 (53-78), bovine 是一种 T 细胞抗原表位，可在 Lewis 大鼠中诱导实验性自身免疫性神经炎 (EAN)。 | |||||
| GC33586 | Tyrosine Protein Kinase JAK 2 Phospho-Tyr8, 9 | 247171-44-4 | Peptides | ||
TyrosineProteinKinaseJAK2(Phospho-Tyr8,9)是小鼠JAK2对应的475到491氨基酸序列的多肽。 | |||||
| GC61808 | Peripheral Myelin P0 Protein (180-199), mouse | 147450-30-4 | Peptides | ||
PeripheralMyelinP0Protein(180-199),mouse是一种神经原性肽，是鼠类外周神经髓磷脂的纯化成分。 | |||||
| GA20096 | (Des-Glu²²)-Amyloid β-Protein (1-42) | 1239313-74-6 | Amyloid β protein | ||
The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity. | |||||
| GA20201 | (Gly²⁸,Cys³⁰)-Amyloid β-Protein (1-30) amide | 1802080-88-1 | Amyloid β protein | ||
| GA20434 | 5-FAM-Amyloid β-Protein (1-42) (scrambled) | - | Amyloid β protein | ||
Fluorescent dye-labeled inactive control for H-1368, H-6466, H-8146. | |||||