关于 "Cytoskeleton & Motor Proteins" 的结果57+ 个结果
- Amyloid β-Protein (5-42)CAS: 1678415-97-8
Abeta 5-42 is produced from amyloid precursor protein by action of caspases. It is deposited in Alzheimer's disease brain as well, but less prone to aggregation.
- Amyloid β-Protein (17-42)CAS: 155178-13-5
Cleavage of APP by alpha- and gamma secretase (i.
Peptides - Protein Kinase C Peptide SubstrateCAS: 120253-69-2
Protein Kinase C Peptide Substrate 依赖于第二信使和特定的适配蛋白靶向特定的细胞间室,接受细胞外信号,激活 G 蛋白偶联受体,酪氨酸激酶受体或酪氨酸激酶偶联受体。Protein Kinase C Peptide Substrate 参与调控多种生理功能,包括神经。内分泌、外分泌、炎症和免疫系统的激活。
Peptides - Microtubule-associated protein tau (26-44)
Microtubule-associated protein tau (26-44) 是一个合成肽链,具有连接到谷氨酰胺的胺基和与赖氨酸连接的羧基。
Peptides - C-Reactive Protein (CRP) 174-185CAS: 160369-86-8
C-Reactive Protein (CRP) 174-185 是 C-反应蛋白的 174-185 片段。C-Reactive Protein 可作为炎症的标记,是心血管风险的标志物,可能促进动脉粥样硬化形成。
Peptides - Acyl Carrier Protein (ACP) (65-74)CAS: 66851-75-0
Acyl Carrier Protein (ACP) (65-74) 是一种有活性的酰基载体蛋白 ACP 片段。
Peptides - Amyloid β-Protein (1-6)CAS: 214550-64-8
Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice.
- Amyloid β-Protein (2-42)CAS: 1678416-22-2
Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages.
- Amyloid β-Protein (3-42)CAS: 157884-74-7
The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate.
- Amyloid β-Protein (4-42)CAS: 157884-72-5
Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases.
- (Gln²²)-Amyloid β-Protein (1-40)CAS: 144410-00-4
The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.
- (Gln²²)-Amyloid β-Protein (1-42)CAS: 147335-12-4
The Dutch mutation (E22Q) aggregates more readily than the wild-type sequence. The resulting fibrils show increased neurotoxicity.
- (Gly²¹)-Amyloid β-Protein (1-40)CAS: 154362-03-5
Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
- (Gly²¹)-Amyloid β-Protein (1-42)CAS: 383200-53-1
The Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. A21G is pathogenic as it is degraded significantly more slowly by neprilysin than WT Abeta42.
- (Gly²²)-Amyloid β-Protein (1-40)CAS: 175010-18-1
The highly neurotoxic arctic mutant (E22G) of Aβ has been used to study the mechanisms underlying the formation of soluble and insoluble β-amyloid aggregates. As the wild-type Aβ, the arctic mutant preferably assembles in the presence of GM1 ganglioside.
- (Gly²²)-Amyloid β-Protein (1-42)CAS: 1802086-23-2
The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GA20750 | Amyloid β-Protein (36-38) | 21835-35-8 | Amyloid β protein | ||
| GA20751 | Amyloid β-Protein (37-39) | 20274-89-9 | Amyloid β protein | ||
| GA20752 | Amyloid β-Protein (40-1) | 144409-99-4 | Amyloid β protein | ||
Reverse sequence of Aβ 1-40. | |||||
| GA20755 | Amyloid β-Protein (5-42) | 1678415-97-8 | Amyloid β protein | ||
Abeta 5-42 is produced from amyloid precursor protein by action of caspases. It is deposited in Alzheimer's disease brain as well, but less prone to aggregation. | |||||
| GA20756 | Amyloid β-Protein (6-20) | 183745-82-6 | Amyloid β protein | ||
| GA24069 | Amyloid β-Protein (17-42) | 155178-13-5 | Peptides | ||
Cleavage of APP by alpha- and gamma secretase (i. | |||||
| GC37016 | Protein Kinase C Peptide Substrate | 120253-69-2 | Peptides | ||
Protein Kinase C Peptide Substrate 依赖于第二信使和特定的适配蛋白靶向特定的细胞间室,接受细胞外信号,激活 G 蛋白偶联受体,酪氨酸激酶受体或酪氨酸激酶偶联受体。Protein Kinase C Peptide Substrate 参与调控多种生理功能,包括神经。内分泌、外分泌、炎症和免疫系统的激活。 | |||||
| GA20824 | Biotinyl-Amyloid β-Protein (1-42) | 1802086-20-9 | Amyloid β protein | ||
N-terminally biotin-labeled Aβ42. | |||||
| GC39406 | Microtubule-associated protein tau (26-44) | - | Peptides | ||
Microtubule-associated protein tau (26-44) 是一个合成肽链,具有连接到谷氨酰胺的胺基和与赖氨酸连接的羧基。 | |||||
| GC35744 | C-Reactive Protein (CRP) 174-185 | 160369-86-8 | Peptides | ||
C-Reactive Protein (CRP) 174-185 是 C-反应蛋白的 174-185 片段。C-Reactive Protein 可作为炎症的标记,是心血管风险的标志物,可能促进动脉粥样硬化形成。 | |||||
| GC68622 | Acyl Carrier Protein (ACP) (65-74) | 66851-75-0 | Peptides | ||
Acyl Carrier Protein (ACP) (65-74) 是一种有活性的酰基载体蛋白 ACP 片段。 | |||||
| GA20733 | Amyloid β-Protein (1-42) | 107761-42-2 | Amyloid β protein | ||
与内盐相比,Aβ42 的盐酸盐在 pH 7.4 时更容易聚集。 | |||||
| GA20738 | Amyloid β-Protein (1-6) | 214550-64-8 | Amyloid β protein | ||
Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. | |||||
| GA20744 | Amyloid β-Protein (2-42) | 1678416-22-2 | Amyloid β protein | ||
Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages. | |||||
| GA20748 | Amyloid β-Protein (3-42) | 157884-74-7 | Amyloid β protein | ||
The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate. | |||||
| GA20754 | Amyloid β-Protein (4-42) | 157884-72-5 | Amyloid β protein | ||
Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases. | |||||
| GA20181 | (Gln¹¹)-Amyloid β-Protein (1-28) | 106686-61-7 | Amyloid β protein | ||
| GA20182 | (Gln²²)-Amyloid β-Protein (1-40) | 144410-00-4 | Amyloid β protein | ||
The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μm, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect. | |||||
| GA20183 | (Gln²²)-Amyloid β-Protein (1-42) | 147335-12-4 | Amyloid β protein | ||
The Dutch mutation (E22Q) aggregates more readily than the wild-type sequence. The resulting fibrils show increased neurotoxicity. | |||||
| GA20186 | (Gln⁹)-Amyloid β-Protein (1-40) | 1802084-59-8 | Amyloid β protein | ||
| GA20197 | (Gly²¹)-Amyloid β-Protein (1-40) | 154362-03-5 | Amyloid β protein | ||
Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant. | |||||
| GA20198 | (Gly²¹)-Amyloid β-Protein (1-42) | 383200-53-1 | Amyloid β protein | ||
The Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. A21G is pathogenic as it is degraded significantly more slowly by neprilysin than WT Abeta42. | |||||
| GA20199 | (Gly²²)-Amyloid β-Protein (1-40) | 175010-18-1 | Amyloid β protein | ||
The highly neurotoxic arctic mutant (E22G) of Aβ has been used to study the mechanisms underlying the formation of soluble and insoluble β-amyloid aggregates. As the wild-type Aβ, the arctic mutant preferably assembles in the presence of GM1 ganglioside. | |||||
| GA20200 | (Gly²²)-Amyloid β-Protein (1-42) | 1802086-23-2 | Amyloid β protein | ||
The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42. | |||||
