关于 "Bromodomain" 的结果4 个结果
筛选:PROTAC×
- ACBI1CAS: 2375564-55-7
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
- Thalidomide-NH-C4-NH-BocCAS: 2093388-52-2
Thalidomide-NH-C4-NH-Boc is a novel, potent, and selective class of Bromodomain-containing protein 4 (BRD4) and Bromodomain-containing protein 2 (BRD2) degrader for the development of therapeutics to treat cancers.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC16531 | Bromodomain Inhibitor, (+)-JQ1 | 1268524-70-4 | Ligand for Target Protein for PROTAC | ||
A selective inhibitor of BET bromodomains | |||||
| GC35227 | ACBI1 | 2375564-55-7 | Other Apoptosis | ||
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. | |||||
| GC34726 | PROTAC BET-binding moiety 2 | 916493-82-8 | Ligand for Target Protein for PROTAC | ||
PROTACBET-bindingmoiety2是BETbromodomain的抑制剂。 | |||||
| GC62722 | Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | E3 Ligase Ligand-Linker Conjugate | ||
Thalidomide-NH-C4-NH-Boc is a novel, potent, and selective class of Bromodomain-containing protein 4 (BRD4) and Bromodomain-containing protein 2 (BRD2) degrader for the development of therapeutics to treat cancers. | |||||