关于 "c-MET" 的结果6 个结果
筛选:Other Apoptosis×
- SAR125844CAS: 1116743-46-4
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
Other Apoptosis
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC11733 | PHA-665752 | 477575-56-7 | Other Apoptosis | ||
A selective c-Met inhibitor | |||||
| GC11089 | SU11274 | 658084-23-2 | Autophagy | ||
A potent, selective inhibitor of c-Met | |||||
| GC13598 | MGCD-265 | 875337-44-3 | Other Apoptosis | ||
A c-Met and VEGFR2 inhibitor | |||||
| GC14256 | Tivantinib (ARQ 197) | 905854-02-6 | Other Apoptosis | ||
An inhibitor of c-Met | |||||
| GC17866 | INCB28060 | 1029712-80-8 | Other Apoptosis | ||
INCB28060是一种高效、口服生物利用度高的c-Met抑制剂,其IC₅₀值为0.13nM。INCB28060用于治疗成人转移性非小细胞肺癌(NSCLC),包括Met外显子14跳跃产生的突变变体的NSCLC患者。 | |||||
| GC33189 | SAR125844 | 1116743-46-4 | Other Apoptosis | ||
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). | |||||
