关于 "Cancer stem cell" 的结果16+ 个结果
- Glaucocalyxin ACAS: 79498-31-0
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
Other Apoptosis - Rotundic acidCAS: 20137-37-5
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
Other Apoptosis - LinderalactoneCAS: 728-61-0
Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 ?M in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.
Other Apoptosis - DemethoxycurcuminCAS: 22608-11-3;24939-17-1
Natural curcuminoid with roles in cancer and inflammation
- Bruceine DCAS: 21499-66-1
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
Other Apoptosis - Y-27632 dihydrochlorideCAS: 129830-38-2
Y-27632 dihydrochloride 作为一种选择性 Rho 激酶抑制剂，是一种新型支气管扩张剂。
Other Apoptosis - BisdemethoxycurcuminCAS: 33171-05-0
Natural curcuminoid with roles in Alzheimer’s, cancer, and inflammation
- SR-4835CAS: 2387704-62-1
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
Other Apoptosis
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC14882 | Salinomycin | 53003-10-4 | Other Apoptosis | ||
A selective cancer stem cell inhibitor | |||||
| GC10171 | Puromycin aminonucleoside | 58-60-6 | Aminopeptidase | ||
A glomerular epithelial cell toxin | |||||
| GC41261 | Flavokawain B | 1775-97-9 | Other Apoptosis | ||
Induces cancer cell apoptosis | |||||
| GC50282 | EC 19 | 1010694-08-2 | Other Apoptosis | ||
Synthetic retinoid; induces differentiation of stem cells | |||||
| GC38606 | Glaucocalyxin A | 79498-31-0 | Other Apoptosis | ||
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells. | |||||
| GC39155 | PI-273 | 925069-34-7 | Other Apoptosis | ||
PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. | |||||
| GC38609 | Rotundic acid | 20137-37-5 | Other Apoptosis | ||
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways. | |||||
| GC38086 | Linderalactone | 728-61-0 | Other Apoptosis | ||
Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 ?M in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae. | |||||
| GN10529 | Demethoxycurcumin | 22608-11-3;24939-17-1 | Autophagy | ||
Natural curcuminoid with roles in cancer and inflammation | |||||
| GC35559 | Bruceine D | 21499-66-1 | Other Apoptosis | ||
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway. | |||||
| GC10512 | Y-27632 dihydrochloride | 129830-38-2 | Other Apoptosis | ||
Y-27632 dihydrochloride 作为一种选择性 Rho 激酶抑制剂，是一种新型支气管扩张剂。 | |||||
| GN10037 | Bisdemethoxycurcumin | 33171-05-0 | Autophagy | ||
Natural curcuminoid with roles in Alzheimer’s, cancer, and inflammation | |||||
| GC16684 | Docetaxel | 114977-28-5 | Other Apoptosis | ||
Docetaxel是紫杉烷类抗有丝分裂化疗药物,IC50为0.2 µM。 | |||||
| GC39175 | SR-4835 | 2387704-62-1 | Other Apoptosis | ||
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors. | |||||
| GC16893 | ICG 001 | 780757-88-2 | Other Apoptosis | ||
ICG001 是一种靶向 Wnt/β-catenin 通路的小分子抑制剂。 | |||||
| GC15281 | K-252c | 85753-43-1 | Other Apoptosis | ||
A cell-permeable PKC inhibitor | |||||