关于 "Cell Cycle/Checkpoint" 的结果7+ 个结果
筛选:MAPK Signaling×
- Rotundic acidCAS: 20137-37-5
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
- Fasudil (HA-1077) HClCAS: 105628-07-7
Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K i 为0.33μM，IC 50 为0.158μM，对ROCK2和PKA、PKC、PKG的IC 50 分别为4.58μM、12.30μM、1.650μM。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC38609 | Rotundic acid | 20137-37-5 | Other Apoptosis | ||
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways. | |||||
| GC15352 | 8-CPT-Cyclic AMP (sodium salt) | 93882-12-3 | PKA | ||
A cell-permeable cAMP analog | |||||
| GC14289 | Fasudil (HA-1077) HCl | 105628-07-7 | PKC | ||
Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。 | |||||
| GC50406 | st-Ht31 | 188425-80-1 | PKA | ||
Inhibits PKA/AKAP interactions; cell permeable | |||||
| GC17818 | Vacquinol-1 | 5428-80-8 | MKK | ||
An activator of cell death in glioblastoma cells | |||||
| GC41740 | (S)-p38 MAPK Inhibitor III | 581098-48-8 | Innate Immunity | ||
A cell-permeable p38 MAP kinase inhibitor | |||||
| GC44211 | MK2 Inhibitor III | 1186648-22-5 | MAPKAPK2 (MK2) | ||
A potent, cell-permeable inhibitor of MK2 | |||||