关于 "Histone Acetyltransferases" 的结果14 个结果

An inhibitor of JMJD2 histone demethylases

A histone demethylase inhibitor

Selective inhibitor of KDM2/7 histone demethylases

PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.

CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.

GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.

A cell-permeable HDAC inhibitor

An inhibitor of 2-oxoglutarate-dependent enzymes

A 2-oxoglutarate oxygenase inhibitor

JIB-04是一种泛选择性Jumonji组蛋白去甲基化酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC 50 值分别为230nM、340nM、855nM、445nM、435nM、1100nM和290nM。

GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。

A KDM2/7 inhibitor

A dual inhibitor of JMJD3 and UTX

GSK-J4 HCl 是一种小分子抑制剂，具有高效的细胞渗透性和药理学选择性抑制剂，可通过抑制 KDM6B 来保持 H3K27 甲基化。