关于 "Rho" 的结果8 个结果
筛选:GPCR/G protein×
- Rhosin hydrochlorideCAS: 1281870-42-5
Rhosin hydrochloride是一种有效的、特异性的RhoA亚家族Rho GTPases小分子抑制剂，能够特异性地结合RhoA并抑制RhoA与鸟嘌呤核苷酸交换因子（GEF）的相互作用，其解离常数（Kd）约为0.4μM。
- MLS000532223CAS: 16616-39-0
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM.
- CCG-222740CAS: 1922098-69-8
CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC33167 | Rhosin | 1173671-63-0 | Other Apoptosis | ||
An inhibitor of the Rho-GEF protein-protein interaction | |||||
| GC32729 | Rhosin hydrochloride | 1281870-42-5 | Other Apoptosis | ||
Rhosin hydrochloride是一种有效的、特异性的RhoA亚家族Rho GTPases小分子抑制剂，能够特异性地结合RhoA并抑制RhoA与鸟嘌呤核苷酸交换因子（GEF）的相互作用，其解离常数（Kd）约为0.4μM。 | |||||
| GC12795 | CCG-1423 | 285986-88-1 | Ras | ||
An inhibitor of Rho-mediated cell signalling | |||||
| GC34088 | Y16 | 429653-73-6 | Ras | ||
Y16 is an inhibitor of G-protein-coupled Rho GEFs. It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). | |||||
| GC14266 | CCG 203971 | 1443437-74-8 | Ras | ||
An inhibitor of the Rho/MKL1/SRF transcriptional pathway | |||||
| GC61076 | MLS000532223 | 16616-39-0 | Ras | ||
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM. | |||||
| GC38898 | CCG-222740 | 1922098-69-8 | ROCK | ||
CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression. | |||||
| GC39763 | Z62954982 | 1090893-12-1 | Ras | ||
Z62954982 (ZINC08010136) 是一种强效的、选择性的、细胞渗透性强的 Rac1 (IC50=12 μM) 抑制剂，比 NSC23766 (IC50=50 μM) 有效性强 4 倍。Z62954982 干扰 Rac1/Tiam1 复合物，降低活性 Rac1 (GTP 结合的 Rac1) 的细胞质水平，而不影响其他 Rho GTPases (如，Cdc42 或 RhoA) 的活性。 | |||||