关于 "Cell Cycle/Checkpoint" 的结果43+ 个结果
- DalpiciclibCAS: 1637781-04-4
Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
- XL413 (BMS-863233)CAS: 1169562-71-3
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.
- Adenylosuccinic Acid (ammonium salt)
A purine nucleotide and an intermediate in the purine nucleotide cycle
- Samuraciclib hydrochloride (ICEC0942 hydrochloride)CAS: 1805789-54-1
Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC16822 | LY2835219 | 1231930-82-7 | CDK | ||
LY2835219是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC50 分别为 2nM 和 10nM。 | |||||
| GC17648 | Dinaciclib(SCH727965) | 779353-01-4 | Other Apoptosis | ||
A CDK inhibitor | |||||
| GC12961 | Apicidin | 183506-66-3 | Histone Demethylases | ||
A cell-permeable HDAC inhibitor | |||||
| GC10842 | LEE011 | 1211441-98-3 | CDK | ||
LEE011是一种具有口服活性的特异性细胞周期蛋白依赖性激酶CDK4/6抑制剂。LEE011以纳摩尔浓度靶向cyclin D1/CDK4和cyclin D3/CDK6。 | |||||
| GC10546 | AZD7762 | 860352-01-8 | Checkpoint Kinase (Chk) | ||
A selective checkpoint kinase inhibitor | |||||
| GC50119 | AZD 7762 hydrochloride | 1246094-78-9 | Checkpoint Kinase (Chk) | ||
A selective checkpoint kinase inhibitor | |||||
| GC63419 | Dalpiciclib | 1637781-04-4 | CDK | ||
Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | |||||
| GC14234 | PF-477736 | 952021-60-2 | Checkpoint Kinase (Chk) | ||
A selective inhibitor of checkpoint kinase 1 | |||||
| GC26084 | XL413 (BMS-863233) | 1169562-71-3 | CDK | ||
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2. | |||||
| GC49231 | Adenylosuccinic Acid (ammonium salt) | - | Nucleotides/Nucleosides | ||
A purine nucleotide and an intermediate in the purine nucleotide cycle | |||||
| GC15739 | CHIR-124 | 405168-58-3 | Other Apoptosis | ||
A selective Chk1 inhibitor | |||||
| GC32735 | Samuraciclib hydrochloride (ICEC0942 hydrochloride) | 1805789-54-1 | CDK | ||
Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis. | |||||
| GC11118 | KU 55933 | 587871-26-9 | Autophagy | ||
KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，Ki值为2.2nM。 | |||||
| GC10293 | VE-821 | 1232410-49-9 | ATM/ATR | ||
An inhibitor of ATR | |||||
| GC12054 | KU-60019 | 925701-46-8 | ATM/ATR | ||
A potent ATM kinase inhibitor | |||||
| GC16489 | CP-466722 | 1080622-86-1 | ATM/ATR | ||
An ATM kinase inhibitor | |||||
| GC15047 | PHA-793887 | 718630-59-2 | Other Apoptosis | ||
A CDK inhibitor | |||||
| GC12438 | AZD-5438 | 602306-29-6 | CDK | ||
A potent inhibitor of CDKs | |||||
| GC15588 | PHA-848125 | 802539-81-7 | Autophagy | ||
An inhibitor of Cdks | |||||
| GC15741 | LY2603618 | 911222-45-2 | Autophagy | ||
A Chk1 inhibitor | |||||
| GC16425 | Flavopiridol hydrochloride | 131740-09-5 | Autophagy | ||
An inhibitor of cyclin-dependent kinases | |||||
| GC14526 | CGK733 | 905973-89-9 | ATM/ATR | ||
An anticancer compound | |||||
| GC10867 | (+)-Aphidicolin | 38966-21-1 | DNA/RNA Synthesis | ||
阿非迪霉素是真核DNA复制的可逆抑制剂，可阻断前S期的细胞周期。 | |||||
| GC15870 | AT7519 | 844442-38-2 | Other Apoptosis | ||
A Cdk inhibitor | |||||