关于 "Cell Cycle/Checkpoint" 的结果20+ 个结果
筛选:Chromatin/Epigenetics×
- BI 2536CAS: 755038-02-9
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC 50 ）值分别为0.83nM、3.5nM和9.0nM。
- Glucosamine (D-Glucosamine)CAS: 3416-24-8
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
- MLN8237 (Alisertib)CAS: 1028486-01-2
Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC12961 | Apicidin | 183506-66-3 | Histone Demethylases | ||
A cell-permeable HDAC inhibitor | |||||
| GC17196 | Hesperadin | 422513-13-1 | Parasite | ||
Hesperadin是一种竞争性ATP结合抑制剂，对Aurora B激酶的IC50为250nM。 | |||||
| GC17534 | GSK343 | 1346704-33-3 | Autophagy | ||
A selective, cell-permeable EZH2 inhibitor | |||||
| GC12450 | BI 2536 | 755038-02-9 | Epigenetic Reader Domain | ||
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC50）值分别为0.83nM、3.5nM和9.0nM。 | |||||
| GC30263 | Glucosamine (D-Glucosamine) | 3416-24-8 | Autophagy | ||
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites. | |||||
| GC12690 | MLN8237 (Alisertib) | 1028486-01-2 | Other Apoptosis | ||
Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。 | |||||
| GC12064 | SB1317 | 937270-47-8 | CDK | ||
A multi-kinase inhibitor | |||||
| GC15106 | CYC116 | 693228-63-6 | Aurora Kinase | ||
A potent Aurora kinase inhibitor | |||||
| GC13332 | Aurora A Inhibitor I | 1158838-45-9 | Other Apoptosis | ||
A potent and selective inhibitor of Aurora A kinase | |||||
| GC34849 | UBCS039 | 358721-70-7 | Autophagy | ||
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines. | |||||
| GC15040 | NSC 3852 | 3565-26-2 | HDAC | ||
A tumor cell differentiating agent | |||||
| GC44184 | Methylstat (hydrate) | - | Histone Demethylases | ||
A cell-permeable demethylase inhibitor | |||||
| GC12781 | XAV-939 | 284028-89-3 | Wnt/β-catenin | ||
XAV-939 选择性抑制 β-连环蛋白介导的转录。 | |||||
| GC13764 | Nexturastat A | 1403783-31-2 | HDAC | ||
A potent, cell-permeable HDAC6 inhibitor | |||||
| GC17275 | AMI-1 | 20324-87-2 | Histone Methyltransferase | ||
A cell permeable inhibitor of PRMTs | |||||
| GC40791 | MS-1020 | 1255516-86-9 | Apoptosis | ||
A cell-permeable inhibitor of JAK3 | |||||
| GC42784 | AMI-1 (sodium salt) | - | HIV | ||
A cell permeable inhibitor of PRMTs | |||||
| GC16117 | INCA-6 | 3519-82-2 | Protein Ser/Thr Phosphatases | ||
A cell-permeant inhibitor of NFAT signaling | |||||
| GC12557 | ML324 | 1222800-79-4 | HSV | ||
A cell-permeable inhibitor of JMJD2 demethylases | |||||
| GC11716 | SIRT1/2 Inhibitor IV | 14513-15-6 | Other Apoptosis | ||
Cell-permeable inhibitor of SIRT1 and SIRT2 | |||||