关于 "Histone Acetyltransferases" 的结果143+ 个结果
- Benzenebutyric acid (4-Phenylbutyric acid)CAS: 1821-12-1
4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
- GSK-J1 lithium salt
GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.
- EntacaponeCAS: 130929-57-6
Entacapone是一种有效的、可逆的、外周作用和具有口服活性的儿茶酚-O-甲基转移酶（COMT）抑制剂，可有效抑制大鼠肝脏总COMT，IC 50 和K i 值分别为20.1nM和10.7nM。
- Trichostatin A (TSA)CAS: 58880-19-6
Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。
- JIB-04CAS: 199596-05-9
JIB-04是一种泛选择性Jumonji组蛋白去甲基化酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC 50 值分别为230nM、340nM、855nM、445nM、435nM、1100nM和290nM。
- GSK J4 free baseCAS: 1373423-53-0
GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。
- EPZ5676CAS: 1380288-87-8
EPZ5676是一种新型的、高效的、选择性DOT1L组蛋白甲基转移酶抑制剂，K i 值小于80pM，对DOT1L的IC 50 为0.8nM，选择性比作用于其他多种蛋白甲基转移酶高37000倍。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC37643 | SIS17 | 2374313-54-7 | HDAC | ||
SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. | |||||
| GC30763 | Benzenebutyric acid (4-Phenylbutyric acid) | 1821-12-1 | Virus Protease | ||
4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models. | |||||
| GC15857 | Sodium butyrate | 156-54-7 | Autophagy | ||
A short-chain fatty acid and HDAC inhibitor | |||||
| GC62104 | WM-3835 | 2229025-70-9 | Apoptosis | ||
WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation. | |||||
| GC36195 | GSK-J1 lithium salt | - | Histone Demethylases | ||
GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C. | |||||
| GC17334 | Entacapone | 130929-57-6 | COMT | ||
Entacapone是一种有效的、可逆的、外周作用和具有口服活性的儿茶酚-O-甲基转移酶（COMT）抑制剂，可有效抑制大鼠肝脏总COMT，IC50和Ki值分别为20.1nM和10.7nM。 | |||||
| GC15526 | Trichostatin A (TSA) | 58880-19-6 | HDAC | ||
Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。 | |||||
| GC12961 | Apicidin | 183506-66-3 | Histone Demethylases | ||
A cell-permeable HDAC inhibitor | |||||
| GC11873 | 2,4-Pyridinedicarboxylic Acid | 499-80-9 | Histone Demethylases | ||
An inhibitor of 2-oxoglutarate-dependent enzymes | |||||
| GC15002 | Sodium Phenylbutyrate | 1716-12-7 | Autophagy | ||
Sodium Phenylbutyrate是一种组蛋白去乙酰化酶（HDAC）抑制剂。 | |||||
| GC15536 | NCH 51 | 848354-66-5 | HDAC | ||
An HDAC inhibitor | |||||
| GC17754 | IOX 1 | 5852-78-8 | Histone Demethylases | ||
A 2-oxoglutarate oxygenase inhibitor | |||||
| GC15603 | JIB-04 | 199596-05-9 | Other Apoptosis | ||
JIB-04是一种泛选择性Jumonji组蛋白去甲基化酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC50值分别为230nM、340nM、855nM、445nM、435nM、1100nM和290nM。 | |||||
| GC12997 | GSK J4 free base | 1373423-53-0 | Histone Demethylases | ||
GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。 | |||||
| GC11340 | (R)-PFI 2 hydrochloride | 1627607-87-7 | Histone Methyltransferase | ||
A SET7/9 inhibitor | |||||
| GC16015 | A 366 | 1527503-11-2 | Histone Methyltransferase | ||
A 366是一种选择性的G9a/GLP组蛋白甲基转移酶抑制剂，可抑制G9a（IC50=3.3nM）和GLP（IC50=38nM）的活性。 | |||||
| GC10319 | TC-E 5002 | 1453071-47-0 | Histone Demethylases | ||
A KDM2/7 inhibitor | |||||
| GC11491 | SGC 0946 | 1561178-17-3 | Histone Methyltransferase | ||
A potent inhibitor of DOT1L | |||||
| GC10617 | GSK J1 | 1373422-53-7 | Histone Demethylases | ||
A dual inhibitor of JMJD3 and UTX | |||||
| GC15315 | Scriptaid | 287383-59-9 | Autophagy | ||
HDAC inhibitor | |||||
| GC17005 | 4-iodo-SAHA | 1219807-87-0 | HDAC | ||
A potent SAHA analog | |||||
| GC13878 | EPZ005687 | 1396772-26-1 | EZH2 | ||
A potent, selective inhibitor of EZH2 | |||||
| GC12932 | EPZ5676 | 1380288-87-8 | Histone Methyltransferase | ||
EPZ5676是一种新型的、高效的、选择性DOT1L组蛋白甲基转移酶抑制剂，Ki值小于80pM，对DOT1L的IC50为0.8nM，选择性比作用于其他多种蛋白甲基转移酶高37000倍。 | |||||
| GC14936 | Chaetocin | 28097-03-2 | Histone Methyltransferase | ||
据报道毛壳素是组蛋白甲基转移酶 (HMT)（例如 SUV39H1）的非特异性抑制剂，从而影响基因表达。 | |||||