关于 "Bromodomain" 的结果52+ 个结果
- ACBI1CAS: 2375564-55-7
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
- AZD5153 6-Hydroxy-2-naphthoic acidCAS: 1869912-40-2
AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
- L Moses dihydrochloride
High affinity and selective PCAF bromodomain inhibitor
- MS645CAS: 2250091-96-2
MS645 是一种 BET bromodomains (BrD) 抑制剂，对于 BRD4-BD1/BD2 的 Ki 值为 18.4 nM。MS645 在空间上限制 BRD4 BrDs 的二价抑制，从而导致实体肿瘤细胞中 BRD4 转录活性的持续抑制。
- GNE-781CAS: 1936422-33-1
GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.
- FL-411 (BRD4-IN-1)CAS: 2118944-88-8
FL-411 (BRD4-IN-1) is a potent and selective inhibitor of Bromodomain-containing protein 4 (BRD4) with IC50 of 0.43 μM for BRD4(1). FL-411 induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction.
- INCB054329CAS: 1628607-64-6
INCB054329 (INCB-054329, INCB-54329) is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM for BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2, respectively.
- Y06036CAS: 1832671-96-1
Y06036 (Compound 6i) is a potent and selective inhibitor of BET with antitumor activity. Y06036 binds to the BRD4(1) bromodomain with Kd of 82 nM.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC10402 | Bromosporine | 1619994-69-2 | Epigenetic Reader Domain | ||
A non-specific bromodomain inhibitor | |||||
| GC16611 | GW841819X | - | Bromodomain | ||
BET bromodomain inhibitor | |||||
| GC13822 | (-)-JQ1 | 1268524-71-5 | Epigenetic Reader Domain | ||
A selective inhibitor of BET bromodomains | |||||
| GC35227 | ACBI1 | 2375564-55-7 | Other Apoptosis | ||
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. | |||||
| GC35297 | Alobresib | 1637771-14-2 | Epigenetic Reader Domain | ||
A BET bromodomain inhibitor | |||||
| GC35448 | AZD5153 6-Hydroxy-2-naphthoic acid | 1869912-40-2 | Epigenetic Reader Domain | ||
AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes. | |||||
| GC36734 | NI-42 | 1884640-99-6 | Epigenetic Reader Domain | ||
An inhibitor of the BRPF1 bromodomain | |||||
| GC36887 | PF-CBP1 hydrochloride | 2070014-93-4 | Histone Acetyltransferases | ||
An inhibitor of the CBP and p300 bromodomains | |||||
| GC50340 | TC AC 28 | 1809296-92-1 | Epigenetic Reader Domain | ||
High affinity BET bromodomain ligand | |||||
| GC50395 | L Moses dihydrochloride | - | Epigenetic Reader Domain | ||
High affinity and selective PCAF bromodomain inhibitor | |||||
| GC50542 | TP 238 | 2415263-04-4 | Epigenetic Reader Domain | ||
A chemical probe for the bromodomains of CECR2 and BPTF | |||||
| GC60182 | GSK046 | 2474876-09-8 | Bromodomain | ||
A BD2 bromodomain inhibitor | |||||
| GC19098 | CeMMEC1 | 440662-09-9 | DNA/RNA Synthesis | ||
A selective TAF1 bromodomain 2 inhibitor | |||||
| GC19210 | JQ-1 carboxylic acid | 202592-23-2 | Epigenetic Reader Domain | ||
A selective inhibitor of BET bromodomains | |||||
| GC19409 | ABBV-744 | 2138861-99-9 | HIV | ||
A BD2 bromodomain inhibitor | |||||
| GC38474 | MS645 | 2250091-96-2 | Epigenetic Reader Domain | ||
MS645 是一种 BET bromodomains (BrD) 抑制剂，对于 BRD4-BD1/BD2 的 Ki 值为 18.4 nM。MS645 在空间上限制 BRD4 BrDs 的二价抑制，从而导致实体肿瘤细胞中 BRD4 转录活性的持续抑制。 | |||||
| GC45640 | TP-238 (hydrochloride) | 2415263-05-5 | Bromodomain | ||
A chemical probe for the bromodomains of CECR2 and BPTF | |||||
| GC45503 | L-Moses (hydrochloride) | - | Histone Acetyltransferases | ||
A PCAF bromodomain inhibitor | |||||
| GC31731 | GSK 4027 | 2079896-25-4 | Histone Acetyltransferases | ||
A PCAF/GCN5 bromodomain inhibitor | |||||
| GC32081 | GNE-781 | 1936422-33-1 | Histone Acetyltransferases | ||
GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity. | |||||
| GC32812 | BMS-986158 | 1800340-40-2 | Epigenetic Reader Domain | ||
A BET bromodomain inhibitor | |||||
| GC33015 | FL-411 (BRD4-IN-1) | 2118944-88-8 | Epigenetic Reader Domain | ||
FL-411 (BRD4-IN-1) is a potent and selective inhibitor of Bromodomain-containing protein 4 (BRD4) with IC50 of 0.43 μM for BRD4(1). FL-411 induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction. | |||||
| GC33026 | INCB054329 | 1628607-64-6 | Epigenetic Reader Domain | ||
INCB054329 (INCB-054329, INCB-54329) is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM for BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2, respectively. | |||||
| GC33285 | Y06036 | 1832671-96-1 | Epigenetic Reader Domain | ||
Y06036 (Compound 6i) is a potent and selective inhibitor of BET with antitumor activity. Y06036 binds to the BRD4(1) bromodomain with Kd of 82 nM. | |||||