关于 "Cell Cycle/Checkpoint" 的结果64+ 个结果
筛选:Cell Cycle/Checkpoint×
- Fasudil (HA-1077) HClCAS: 105628-07-7
Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K i 为0.33μM，IC 50 为0.158μM，对ROCK2和PKA、PKC、PKG的IC 50 分别为4.58μM、12.30μM、1.650μM。
- BI 2536CAS: 755038-02-9
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC 50 ）值分别为0.83nM、3.5nM和9.0nM。
- MK-8776(SCH-900776)CAS: 891494-63-6
MK-8776(SCH-900776) 是一种新型、选择性更高的Chk1抑制剂，旨在通过废除细胞周期阻滞来增强DNA损伤剂和抗代谢物的细胞毒性。
- BOS-172722CAS: 1578245-44-9
BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC12054 | KU-60019 | 925701-46-8 | ATM/ATR | ||
A potent ATM kinase inhibitor | |||||
| GC16489 | CP-466722 | 1080622-86-1 | ATM/ATR | ||
An ATM kinase inhibitor | |||||
| GC14289 | Fasudil (HA-1077) HCl | 105628-07-7 | PKC | ||
Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。 | |||||
| GC11621 | GW843682X | 660868-91-7 | PLK | ||
A reversible polo-like kinase inhibitor | |||||
| GC18119 | GSK429286A | 864082-47-3 | ROCK | ||
A ROCK inhibitor | |||||
| GC15047 | PHA-793887 | 718630-59-2 | Other Apoptosis | ||
A CDK inhibitor | |||||
| GC12438 | AZD-5438 | 602306-29-6 | CDK | ||
A potent inhibitor of CDKs | |||||
| GC12335 | GSK461364 | 929095-18-1 | PLK | ||
A reversible inhibitor of Plk1 | |||||
| GC15588 | PHA-848125 | 802539-81-7 | Autophagy | ||
An inhibitor of Cdks | |||||
| GC15741 | LY2603618 | 911222-45-2 | Autophagy | ||
A Chk1 inhibitor | |||||
| GC16425 | Flavopiridol hydrochloride | 131740-09-5 | Autophagy | ||
An inhibitor of cyclin-dependent kinases | |||||
| GC10163 | MLN0905 | 1228960-69-7 | PLK | ||
A Plk1 inhibitor | |||||
| GC13903 | Ro3280 | 1062243-51-9 | PLK | ||
A selective Plk1 inhibitor | |||||
| GC12795 | CCG-1423 | 285986-88-1 | Ras | ||
An inhibitor of Rho-mediated cell signalling | |||||
| GC12450 | BI 2536 | 755038-02-9 | Epigenetic Reader Domain | ||
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC50）值分别为0.83nM、3.5nM和9.0nM。 | |||||
| GC14526 | CGK733 | 905973-89-9 | ATM/ATR | ||
An anticancer compound | |||||
| GC15870 | AT7519 | 844442-38-2 | Other Apoptosis | ||
A Cdk inhibitor | |||||
| GC16374 | MK-8776(SCH-900776) | 891494-63-6 | Checkpoint Kinase (Chk) | ||
MK-8776(SCH-900776) 是一种新型、选择性更高的Chk1抑制剂，旨在通过废除细胞周期阻滞来增强DNA损伤剂和抗代谢物的细胞毒性。 | |||||
| GC12865 | BMS265246 | 582315-72-8 | CDK | ||
A cell-permeable inhibitor of Cdk1 and Cdk2 | |||||
| GC17400 | R547 | 741713-40-6 | CDK | ||
A selective Cdk inhibitor | |||||
| GC32846 | BOS-172722 | 1578245-44-9 | Mps1 | ||
BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM. | |||||
| GC17105 | CCT241533 hydrochloride | 1431697-96-9 | Checkpoint Kinase (Chk) | ||
A selective Chk2 inhibitor | |||||
| GC13690 | BS-181 HCl | 1397219-81-6 | CDK | ||
A selective Cdk7 inhibitor | |||||
| GC65994 | WEE1-IN-5 | 2243882-74-6 | Wee1 | ||
Debio 0123 is an inhibitor of Wee1 kinase which is a key regulator of the G2/M and S phase checkpoints. | |||||