关于 "Cell Cycle/Checkpoint" 的结果20+ 个结果

筛选:CDK×

GC16822
LY2835219
CAS: 1231930-82-7
LY2835219是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC 50 分别为 2nM 和 10nM。
CDK
GC17648
Dinaciclib(SCH727965)
CAS: 779353-01-4
A CDK inhibitor
Other Apoptosis
GC10842
LEE011
CAS: 1211441-98-3
LEE011是一种具有口服活性的特异性细胞周期蛋白依赖性激酶CDK4/6抑制剂。LEE011以纳摩尔浓度靶向cyclin D1/CDK4和cyclin D3/CDK6。
CDK
GC63419
Dalpiciclib
CAS: 1637781-04-4
Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
CDK
GC26084
XL413 (BMS-863233)
CAS: 1169562-71-3
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.
CDK
GC32735
Samuraciclib hydrochloride (ICEC0942 hydrochloride)
CAS: 1805789-54-1
Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.
CDK
GC15047
PHA-793887
CAS: 718630-59-2
A CDK inhibitor
Other Apoptosis
GC12438
AZD-5438
CAS: 602306-29-6
A potent inhibitor of CDKs
CDK
GC15588
PHA-848125
CAS: 802539-81-7
An inhibitor of Cdks
Autophagy
GC16425
Flavopiridol hydrochloride
CAS: 131740-09-5
An inhibitor of cyclin-dependent kinases
Autophagy
GC15870
AT7519
CAS: 844442-38-2
A Cdk inhibitor
Other Apoptosis
GC12865
BMS265246
CAS: 582315-72-8
A cell-permeable inhibitor of Cdk1 and Cdk2
CDK
GC17400
R547
CAS: 741713-40-6
A selective Cdk inhibitor
CDK
GC13690
BS-181 HCl
CAS: 1397219-81-6
A selective Cdk7 inhibitor
CDK
GC17935
PD 0332991 (Palbociclib) HCl
CAS: 827022-32-2
PD 0332991 作为 CDK4 和 CDK6 激酶的口服活性强效和高选择性抑制剂，可以在低纳摩尔浓度下阻断 pRb 磷酸化并随后在敏感细胞系中诱导 G1 期停滞。
CDK
GC12064
SB1317
CAS: 937270-47-8
A multi-kinase inhibitor
CDK
GC13998
AT7519 Hydrochloride
CAS: 902135-91-5
A Cdk inhibitor
Other Apoptosis
GC11396
SNS-032 (BMS-387032)
CAS: 345627-80-7
A Cdk2, Cdk7, and Cdk9 inhibitor
Other Apoptosis
GC15421
Palbociclib (PD0332991) Isethionate
CAS: 827022-33-3
Palbociclib (PD 0332991) isethionate 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 Palbociclib (PD0332991) Isethionate 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
CDK
GC11401
Roscovitine (Seliciclib,CYC202)
CAS: 186692-46-6
Roscovitine (Seliciclib,CYC202)是一种有效的Cdk2/cyclin E抑制剂，IC 50 值为0.1μM。Roscovitine还抑制Cdk7/cyclin H、Cdk5/p35以及（cdc）/cyclin B，IC 50 值分别为0.49、0.16和0.65μM。
CDK

搜索结果产品列表
货号	产品名称	CAS号	靶点 / 通路
GC16822	LY2835219	1231930-82-7	CDK
GC16822	LY2835219是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC₅₀ 分别为 2nM 和 10nM。
GC17648	Dinaciclib(SCH727965)	779353-01-4	Other Apoptosis
GC17648	A CDK inhibitor
GC10842	LEE011	1211441-98-3	CDK
GC10842	LEE011是一种具有口服活性的特异性细胞周期蛋白依赖性激酶CDK4/6抑制剂。LEE011以纳摩尔浓度靶向cyclin D1/CDK4和cyclin D3/CDK6。
GC63419	Dalpiciclib	1637781-04-4	CDK
GC63419	Dalpiciclib (SHR-6390), a highly selective, orally bioavailable CDK4/6 inhibitor with comparable potencies against CDK4 and CDK6, exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor-suppressor retinoblastoma protein (Rb) and inducing G1 cell cycle arrest. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
GC26084	XL413 (BMS-863233)	1169562-71-3	CDK
GC26084	XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.
GC32735	Samuraciclib hydrochloride (ICEC0942 hydrochloride)	1805789-54-1	CDK
GC32735	Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.
GC15047	PHA-793887	718630-59-2	Other Apoptosis
GC15047	A CDK inhibitor
GC12438	AZD-5438	602306-29-6	CDK
GC12438	A potent inhibitor of CDKs
GC15588	PHA-848125	802539-81-7	Autophagy
GC15588	An inhibitor of Cdks
GC16425	Flavopiridol hydrochloride	131740-09-5	Autophagy
GC16425	An inhibitor of cyclin-dependent kinases
GC15870	AT7519	844442-38-2	Other Apoptosis
GC15870	A Cdk inhibitor
GC12865	BMS265246	582315-72-8	CDK
GC12865	A cell-permeable inhibitor of Cdk1 and Cdk2
GC17400	R547	741713-40-6	CDK
GC17400	A selective Cdk inhibitor
GC13690	BS-181 HCl	1397219-81-6	CDK
GC13690	A selective Cdk7 inhibitor
GC17935	PD 0332991 (Palbociclib) HCl	827022-32-2	CDK
GC17935	PD 0332991 作为 CDK4 和 CDK6 激酶的口服活性强效和高选择性抑制剂，可以在低纳摩尔浓度下阻断 pRb 磷酸化并随后在敏感细胞系中诱导 G1 期停滞。
GC12064	SB1317	937270-47-8	CDK
GC12064	A multi-kinase inhibitor
GC13998	AT7519 Hydrochloride	902135-91-5	Other Apoptosis
GC13998	A Cdk inhibitor
GC11396	SNS-032 (BMS-387032)	345627-80-7	Other Apoptosis
GC11396	A Cdk2, Cdk7, and Cdk9 inhibitor
GC15421	Palbociclib (PD0332991) Isethionate	827022-33-3	CDK
GC15421	Palbociclib (PD 0332991) isethionate 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 Palbociclib (PD0332991) Isethionate 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
GC11401	Roscovitine (Seliciclib,CYC202)	186692-46-6	CDK
GC11401	Roscovitine (Seliciclib,CYC202)是一种有效的Cdk2/cyclin E抑制剂，IC₅₀值为0.1μM。Roscovitine还抑制Cdk7/cyclin H、Cdk5/p35以及（cdc）/cyclin B，IC₅₀值分别为0.49、0.16和0.65μM。