关于 "BTK" 的结果65+ 个结果

A potent, selective, and irreversible BTK inhibitor

PCI-32765 (Ibrutinib) 是一种不可逆的选择性布鲁顿氏酪氨酸激酶 (BTK) 抑制剂，可选择性靶向其激酶结构域并通过降低其磷酸化能力来调节 BTK 下游信号传导，在无细胞试验中 IC50 为 0.5 nM 。

Pirtobrutinib是一种高选择性、非共价、可逆的Bruton's tyrosine kinase (BTK)抑制剂，对BTK和BTK C481S 的IC 50 值分别为3.2nM和1.4nM。

JS25是一种选择性共价BTK抑制剂，通过螯合Tyr551使BTK失活，IC50值为5.8 nM。

MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).

QL47不可逆的BTK抑制剂，IC50为7 nM。

NRX-0492是一种口服有效的BTK降解剂。

Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.

TAK-020 是一种Btk共价抑制剂，成为临床候选药物。

RSH-7是一种有效的BTK和FLT3抑制剂，ic50分别为47,12 nM。

PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.

PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。

Elsubrutinib (ABBV-105) 是一种具有口服活性、有效的、有选择性和不可逆的 Bruton's tyrosine kinase (BTK) 抑制剂。Elsubrutinib 对 BTK 催化结构域的 IC50 为 0.18 μM。Elsubrutinib 可用于炎症性疾病的研究。

KIN-8194是一种口服活性的HCK和BTK双抑制剂，IC50值分别为0.915和<0.495 nM。

SJF620 hydrochloride 是一种 PROTAC BTK 降解剂，DC50 为 7.9 nM。SJF620 含有 Lenalidomide 类似物，可募集 CRBN。

JNJ-64264681是一种强效、口服活性、选择性和不可逆的共价BTK抑制剂。

TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with IC50 and Ki of 1.5 nM and 11.9 nM, respectively.

Atuzabrutinib（SAR 444727）是一种强效、选择性可逆的Btk（布鲁顿酪氨酸激酶）抑制剂。

Ibrutinibdeacryloylpiperidine(IBT4A)是Ibrutinib的一种杂质。Ibrutinib是一种不可逆的选择性Btk抑制剂，IC50为0.5nM。

BIIB091 是一种高选择性可逆性 BTK 抑制剂，用于治疗自身免疫性疾病的。

(±)-Zanubrutinib ((±)-BGB-3111) ((±)-BGB-3111) 是一种有效的、选择性的和口服的 Bruton's 酪氨酸激酶 (Btk) 抑制剂。

Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) 是共价，高选择性和口服活性的 Btk 抑制剂，IC50 为0.5 nM。

UBX-382是一种口服蛋白水解靶向嵌合体（PROTACs），靶向BTK使b细胞受体信号失活。