关于 "Nucleoside Antimetabolite/Analogue" 的结果10+ 个结果
- Pemetrexed disodium hemipenta hydrateCAS: 357166-30-4
Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂,LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM,用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。
Autophagy - 3'-HydroxypterostilbeneCAS: 475231-21-1
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
Autophagy - 6-Hydroxydopamine hydrobromideCAS: 636-00-0
6-Hydroxydopamine hydrobromide (6-OHDA) 是儿茶酚胺、多巴胺和去甲肾上腺素的结构类似物,对儿茶酚胺能神经元发挥毒性作用。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC16805 | Gemcitabine | 95058-81-4 | Autophagy | ||
An anticancer nucleoside analog | |||||
| GC14961 | Cytarabine hydrochloride | 69-74-9 | Autophagy | ||
A nucleoside analog and prodrug form of ara-CTP | |||||
| GC14366 | Thioguanine | 154-42-7 | SARS-CoV | ||
Thioguanine是一种抗白血病和免疫抑制剂,对重组USP2和冠状病毒PLpro的IC50值分别为40µM和25µM。 | |||||
| GC10518 | AICAR | 2627-69-2 | Mitophagy | ||
AICAR(也称为 acadesine)是一种嘌呤核苷。 | |||||
| GC17694 | Pemetrexed disodium hemipenta hydrate | 357166-30-4 | Autophagy | ||
Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂,LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM,用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。 | |||||
| GC15219 | Clofarabine | 123318-82-1 | DNA/RNA Synthesis | ||
A ribonucleotide reductase and DNA polymerase-α inhibitor | |||||
| GC35112 | 3'-Hydroxypterostilbene | 475231-21-1 | Autophagy | ||
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. | |||||
| GC14106 | Adenosine | 58-61-7 | Endogenous Metabolite | ||
Adenosine是一种内源性神经调节物质,包含腺嘌呤,通过β-N9-糖苷键与核糖分子(呋喃核糖)部分连接。 | |||||
| GC16267 | 6-Hydroxydopamine hydrobromide | 636-00-0 | Mitophagy | ||
6-Hydroxydopamine hydrobromide (6-OHDA) 是儿茶酚胺、多巴胺和去甲肾上腺素的结构类似物,对儿茶酚胺能神经元发挥毒性作用。 | |||||
| GN10503 | Piceatannol | 10083-24-6 | Autophagy | ||
Piceatannol(3,3 ',4,5 ' -反式三羟基二苯乙烯)是天然存在的白藜芦醇羟基化类似物。 | |||||
