关于 "Nucleoside Antimetabolite/Analogue" 的结果19+ 个结果
- Methotrexate disodiumCAS: 7413-34-5
Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties.
- TAS-102CAS: 733030-01-8
An orally bioavailable combination of a nucleoside analog and TPase inhibitor
- Pemetrexed disodium hemipenta hydrateCAS: 357166-30-4
Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂，LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM，用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。
- Voreloxin HydrochlorideCAS: 175519-16-1
Voreloxin Hydrochloride 是一流的拓扑异构酶 II 抑制剂，可嵌入 DNA 并诱导位点选择性 DNA DSB、G2 停滞和细胞凋亡。
- 3'-HydroxypterostilbeneCAS: 475231-21-1
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC12709 | XL147 | 956958-53-5 | Other Apoptosis | ||
An analog of XL147 | |||||
| GA23337 | Oxythiamine . HCl | 614-05-1 | G1 | ||
A thiamine antimetabolite | |||||
| GC61047 | Methotrexate disodium | 7413-34-5 | DNA/RNA Synthesis | ||
Methotrexate sodium, an inhibitor of tetrahydrofolate dehydrogenase, is an antineoplastic antimetabolite with immunosuppressant properties. | |||||
| GC41612 | 2'-O-Methylguanosine | 2140-71-8 | Apoptosis | ||
A modified nucleoside | |||||
| GC36393 | Kinetin riboside | 4338-47-0 | Other Apoptosis | ||
An anticancer nucleoside | |||||
| GC45385 | Ara-G | 38819-10-2 | Drug Metabolite | ||
An anticancer nucleoside analog | |||||
| GC32708 | Forodesine hydrochloride (BCX-1777) | 284490-13-7 | Other Apoptosis | ||
A nucleoside analog and PNP inhibitor | |||||
| GC33029 | Forodesine (BCX-1777 freebase) | 209799-67-7 | Other Apoptosis | ||
A nucleoside analog and PNP inhibitor | |||||
| GC18796 | Herbicidin A | 55353-31-6 | Transcription Factors | ||
An adenine nucleoside antibiotic with herbicidal activity | |||||
| GC10509 | Cladribine | 4291-63-8 | DNA/RNA Synthesis | ||
A nucleoside analog and prodrug form of 2-CdATP | |||||
| GC19348 | TAS-102 | 733030-01-8 | Thymidylate Synthase | ||
An orally bioavailable combination of a nucleoside analog and TPase inhibitor | |||||
| GC10591 | Nelarabine | 121032-29-9 | DNA/RNA Synthesis | ||
A nucleoside analog used in the treatment of leukemia | |||||
| GC17430 | 2-Deoxy-D-glucose | 154-17-6 | Other Apoptosis | ||
2-Deoxy-D-glucose (2DG)，是一种葡萄糖类似物，作为竞争性糖酵解抑制剂。 | |||||
| GC14366 | Thioguanine | 154-42-7 | SARS-CoV | ||
Thioguanine是一种抗白血病和免疫抑制剂，对重组USP2和冠状病毒PLpro的IC50值分别为40µM和25µM。 | |||||
| GC17694 | Pemetrexed disodium hemipenta hydrate | 357166-30-4 | Autophagy | ||
Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂，LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM，用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。 | |||||
| GC15219 | Clofarabine | 123318-82-1 | DNA/RNA Synthesis | ||
A ribonucleotide reductase and DNA polymerase-α inhibitor | |||||
| GC14022 | Voreloxin Hydrochloride | 175519-16-1 | Other Apoptosis | ||
Voreloxin Hydrochloride 是一流的拓扑异构酶 II 抑制剂，可嵌入 DNA 并诱导位点选择性 DNA DSB、G2 停滞和细胞凋亡。 | |||||
| GC35112 | 3'-Hydroxypterostilbene | 475231-21-1 | Autophagy | ||
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. | |||||
| GN10503 | Piceatannol | 10083-24-6 | Autophagy | ||
Piceatannol(3,3 '，4,5 ' -反式三羟基二苯乙烯)是天然存在的白藜芦醇羟基化类似物。 | |||||