关于 "Cell Cycle/Checkpoint" 的结果38+ 个结果
- PI-273CAS: 925069-34-7
PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
- OTS514 hydrochlorideCAS: 2319647-76-0
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
- Glaucocalyxin ACAS: 79498-31-0
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
- Rotundic acidCAS: 20137-37-5
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
- LinderalactoneCAS: 728-61-0
Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 ?M in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.
- TributyrinCAS: 60-01-5
Glycerol tributyrate (Tributyrin) is a triglyceride that may inhibit cell growth and induce cell differentiation.
Apoptosis - BI 2536CAS: 755038-02-9
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC 50 ）值分别为0.83nM、3.5nM和9.0nM。
- MLN8237 (Alisertib)CAS: 1028486-01-2
Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC10512 | Y-27632 dihydrochloride | 129830-38-2 | Other Apoptosis | ||
Y-27632 dihydrochloride 作为一种选择性 Rho 激酶抑制剂，是一种新型支气管扩张剂。 | |||||
| GC16684 | Docetaxel | 114977-28-5 | Other Apoptosis | ||
Docetaxel是紫杉烷类抗有丝分裂化疗药物,IC50为0.2 µM。 | |||||
| GP10036 | p53 tumor suppressor fragment | - | p53 | ||
Regulates cell cycle | |||||
| GC14731 | MTT | 298-93-1 | Apoptosis | ||
A cell-permeable and positively charged tetrazolium dye | |||||
| GC10171 | Puromycin aminonucleoside | 58-60-6 | Aminopeptidase | ||
A glomerular epithelial cell toxin | |||||
| GC39155 | PI-273 | 925069-34-7 | Other Apoptosis | ||
PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. | |||||
| GC17648 | Dinaciclib(SCH727965) | 779353-01-4 | Other Apoptosis | ||
A CDK inhibitor | |||||
| GC25691 | OTS514 hydrochloride | 2319647-76-0 | Other Apoptosis | ||
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis. | |||||
| GC38606 | Glaucocalyxin A | 79498-31-0 | Other Apoptosis | ||
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells. | |||||
| GC12861 | Z-VAD-FMK | 187389-52-2 | Caspase | ||
Z-VAD-FMK（苄氧羰基-Val-Ala-Asp（OMe）氟甲基酮），是一种类似ICE的蛋白酶抑制剂，通过阻止CPP32转化为其活性形式来抑制细胞凋亡。 | |||||
| GC12961 | Apicidin | 183506-66-3 | Histone Demethylases | ||
A cell-permeable HDAC inhibitor | |||||
| GC62174 | ON1231320 | 1312471-39-8 | Apoptosis | ||
ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis. | |||||
| GC38609 | Rotundic acid | 20137-37-5 | Other Apoptosis | ||
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways. | |||||
| GC38086 | Linderalactone | 728-61-0 | Other Apoptosis | ||
Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 ?M in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae. | |||||
| GC15739 | CHIR-124 | 405168-58-3 | Other Apoptosis | ||
A selective Chk1 inhibitor | |||||
| GC61349 | Tributyrin | 60-01-5 | Apoptosis | ||
Glycerol tributyrate (Tributyrin) is a triglyceride that may inhibit cell growth and induce cell differentiation. | |||||
| GC11511 | Vincristine sulfate | 2068-78-2 | Other Apoptosis | ||
An antimitotic inhibitor of tubulin polymerization | |||||
| GC43105 | C8 Ceramide (d18:1.8:0) | 74713-59-0 | PKC | ||
A cell-permeable ceramide analog | |||||
| GC15047 | PHA-793887 | 718630-59-2 | Other Apoptosis | ||
A CDK inhibitor | |||||
| GC12450 | BI 2536 | 755038-02-9 | Epigenetic Reader Domain | ||
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC50）值分别为0.83nM、3.5nM和9.0nM。 | |||||
| GC15870 | AT7519 | 844442-38-2 | Other Apoptosis | ||
A Cdk inhibitor | |||||
| GC12690 | MLN8237 (Alisertib) | 1028486-01-2 | Other Apoptosis | ||
Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。 | |||||
| GC13332 | Aurora A Inhibitor I | 1158838-45-9 | Other Apoptosis | ||
A potent and selective inhibitor of Aurora A kinase | |||||
| GC13998 | AT7519 Hydrochloride | 902135-91-5 | Other Apoptosis | ||
A Cdk inhibitor | |||||