关于 "Bromodomain" 的结果4 个结果
筛选:Apoptosis×
- ACBI1CAS: 2375564-55-7
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC14699 | CPI-203 | 1446144-04-2 | Other Apoptosis | ||
A bioavailable inhibitor of BET bromodomains | |||||
| GC15375 | PFI-1 (PF-6405761) | 1403764-72-6 | Autophagy | ||
A BET bromodomain inhibitor | |||||
| GC35227 | ACBI1 | 2375564-55-7 | Other Apoptosis | ||
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. | |||||
| GC62654 | GSK778 | 2451862-42-1 | Apoptosis | ||
GSK778 (iBET-BD1) is a strong BD1 bromodomain inhibitor of the BET proteins, with IC50 value of 75 nM for BRD2 BD1, 41 nM for BRD3 BD1, 41 nM for BRD4 BD1, and 143 nM for BRDT BD1. | |||||