关于 "Cytoskeleton & Motor Proteins" 的结果111+ 个结果

Anderson and Webb could verify using transmission electron microscopy that N-terminal labeling of Aβ40 with TAMRA and other fluorescent dyes does not prevent the formation of protofibrils and amyloid fibrils of various widths.

Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.

Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.

The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.

Amyloid β/A4 Protein Precursor??? (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.

The flexible LC spacer increases the accessibility of the biotin moiety.

The flexible LC spacer increases the accessibility of the biotin moiety.

β-Amyloid Protein Precursor 770 (135-155) 是 β 淀粉样前体蛋白的一个亚型 (APP 770) 的多肽片段。APP 770 产生 Aβ40/42。

Dimer of H-7402.

The Osaka (E22delta) mutation of Amyloid β promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity.

Fluorescent dye-labeled inactive control for H-1368, H-6466, H-8146.

This peptide is a specifically designed negative control in studies with Abeta40. It is "scrambled", which means it contains the same amino acids as Abeta40, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-40) does not show a number of phenomena regularly observed with Abeta40 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.

This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.

β-Amyloid 22-35 (Amyloid β-Protein (22-35))是一种由14个氨基酸组成的多肽片段，能够自发聚集形成β-折叠结构，并对海马神经元产生显著的细胞毒性作用。

β-Amyloid 29-40 (Amyloid beta-protein(29-40)) 是 Amyloid-β 的一个片段；肽。

β-Amyloid 1-16 (Amyloid β-Protein (1-16)) 是 ⋲-Amyloid 蛋白片段，参与金属结合。

β-Amyloid 1-28 (Amyloid β-Protein (1-28)) 是 β-Amyloid 蛋白片段，参与金属结合。

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It mimicks the wild-type (JMV2235) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is cleaved by BACE1, BACE2, and cathepsin D.

五肽 Ac-LPFFD-NH? (iAβ5p) 是产品 H-4876 的类似物，具有少量化学修饰，可增强其抗蛋白水解降解的稳定性。 iAβ5p 充当 77777#946;-片断肽并以比已知被大脑选择性吸收的大多数蛋白质和肽更高的速率穿过血脑屏障，因此假设该肽被特异性运输到大脑。 iAβ5p 还报道了两种不同的转基因阿尔茨海默病 (AD) 模型中与淀粉样斑块减少相关的神经元存活显着增加和脑部炎症减少。