Satralizumab, a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research[1][2].
Satralizumab (120 mg, Subcutaneously, once every 2 weeks, for 4 weeks) prevents dTAA formation and progression in rattus norvegicus[1].
| Animal Model: | Rattus norvegicus (forty, male, 10-week-old, four equal groups)[1] |
| Dosage: | 120 mg |
| Administration: | Subcutaneously, once every 2 weeks, for 4 weeks |
| Result: | Prevented dTAA (descending thoracic aorta aneurysm) formation and progression. |