Samatasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A).1 It inhibits HCV replication in stable replicon cell lines containing NS5A from genotypes 1a, -1b, -2a, -3a, -4a, and -5a (EC50s = 2-24 pM). Samatasvir acts additively with the nucleotide prodrug IDX184, NS5B inhibitor TMC647055, or NS3/4A protease inhibitor simeprevir to inhibit viral replication in genotype 1b HCV replicon cells.
1.Bilello, J.P., Lallos, L.B., McCarville, J.F., et al.In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virusAntimicrob. Agents Chemother.58(8)4431-4442(2014)