Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria[1][2].
Salannin (10, 20, 50 mg/kg; p.o.) shows a significant protective activity on Aspirin induced gastric lesions[2].
| Animal Model: | Wistar rats, weighing 200-220 g (acetyl salicylic acid induced gastric lesions)[2] |
| Dosage: | 10, 20 and 50 mg/kg |
| Administration: | P.o. |
| Result: | Significantly and dose dependently inhibited acetyl salicylic acid-induced gastric lesions. |
[1]. Divakar C. Madhu, et al. NTIULCER. ANTIBACTERIAL AND SPERMICIDAL ACTIVITIES OF SALANNIN.
[2]. Mohammad Asif, et al. A Review on Spermicidal Activities of Azadirachta indica. Journal of Pharmacognosy and Phytochemistry.