SAINT C-18 is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules.1,2,3,4 Complexes of SAINT C-18 with plasmid DNA encoding pigment epithelium-derived factor (PEDF) inhibit corneal neovascularization induced by complexes of SAINT C-18 with plasmid DNA encoding FGF2, also known as basic FGF, in rats.[2]
References:
[1].van der Woude, I., Wagenaar, A., Meekel, A.A.P., et al.Novel pyridinium surfactants for efficient, nontoxic in vitro gene deliveryProc. Natl. Acad. Sci. USA94(4)1160-1165(1997).
[2].Kuo, C.-N., Yang, L.-C., Yang, C.-T., et al.Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesisExp. Eye Res.89(5)678-685(2009).
[3].van der Gun, B.T.F., Monami, A., Laarmann, S., et al.Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2J. Control Release123(3)228-238(2007).
[4].Adrian, J.E., Morselt, H.W., Süss, R., et al.Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cellsJ. Control Release144(3)341-349(2010).