GlpBio

S07-2010

目录号: GC69848纯度: >99.00%
S07-2010 是一种有效的泛 AKR1C (醛缩酮还原酶家族 1 成员 C) 抑制剂，其对 AKR1C3、AKR1C4、AKR1C1 和 AKR1C2 的 IC50 分别为 0.19、0.36、0.47 和 0.73 μM。S07-2010 可诱导 A549/DDP 细胞凋亡 (apoptosis)。S07-2010 增强了化疗活性分子对耐药细胞的细胞毒性。S07-2010 对耐药细胞增殖有明显抑制作用。
S07-2010
Cas No.: 1223194-71-5
规格价格库存数量操作
10mg¥1,530.00现货
1
25mg¥2,970.00现货
1
50mg¥4,770.00现货
1
100mg¥7,650.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

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产品描述 Description

IC50: 0.19 ± 0.08 μM (AKR1C3), 0.36 ± 0.15 μM (AKR1C4), 0.47 ± 0.16 μM (AKR1C1), 0.73 ± 0.35 μM (AKR1C2)[1]

S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells[1].

S07-2010 (0-25 μM, 48h) exhibits obvious cytotoxicity on MCF-7/DOX and A549/DDP, with IC50 values of 127.5 and 5.51 μM, respectively[1].

[1]. Siyu He, et al. Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance. ACS Med. Chem. Lett. 2022.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1223194-71-5
分子式
C19H21N3O3S
分子量
371.45 g/mol
溶解性
DMSO : 41.67 mg/mL (112.18 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol