GlpBio

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

目录号: GC62684纯度: >99.00%同义词: VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) 是一种 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate) ，包含 VHL 配体。
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
Cas No.: 2086301-47-3
规格价格库存数量操作
1mg¥1,080.00现货
1
5mg¥2,880.00现货
1
10mg¥4,680.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

产品描述 Description

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-991.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
2086301-47-3
同义词
VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
分子式
C39H58N6O7S
分子量
754.98 g/mol
溶解性
DMSO : 220 mg/mL (291.40 mM; Need ultrasonic)
保存条件
Store at -20°C, sealed storage, away from moisture and light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol