GlpBio

S-Me-DM4

目录号: GC71057纯度: >99.00%
S-Me-DM4是DM4 s被胞内酶甲基化的代谢物。
S-Me-DM4
Cas No.: 890654-03-2
规格价格库存数量操作
1 mg¥3,150.00现货
1
5 mg¥7,290.00现货
1
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文献被引

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule.

References:
[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
890654-03-2
分子式
C39H56ClN3O10S
分子量
794.39 g/mol
溶解性
DMSO : 100 mg/mL (125.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
保存条件
-20°C, protect from light, stored under nitrogen
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol