(S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200 .[1] It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intravenous administration of LNPs containing (S)-C12-200 and encapsulating mRNA encoding Cre recombinase increase the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice greater than (R)-C12-200-containing and Cre mRNA-encapsulating LNPs.
References:
[1].Da Silva Sanchez, A.J., Zhao, K., Huayamares, S.G., et al.Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA deliveryJ. Control Release353270-277(2023).