S-(2,4-Dinitrophenyl)-glutathione is a substrate for glutathione-S-transferase with a kinetic dissociation constant of 7 uM. [1] In vitro, it is transported by multidrug resistance protein 1 (MDR1) and MDR3, which are transporters that confer resistance to some chemotherapeutics.[2]
Reference:
[1]. Schramm, V.L., McCluskey, R., Emig, F.A., et al. Kinetic studies and active site-binding properties of glutathione S-transferase using spin-labeled glutathione, a product analogue. J. Biol. Chem. 259(2), 714-722 (1984).
[2]. Zeng, H., Liu, G., Rea, P.A., et al. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 60(17), 4779-4784 (2000).