(RXR)4XB TFA is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO intobacterialcells. (RXR)4XB TFA-PMO conjugate prevents the formation of biofilms, inhibitsPseudomonas aeruginosawithMIC50of 0.5 to 16 μM, and reduces thebacterialburden in mouse acute pneumonia models[1].
References:
[1].Howard JJ, et al., Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e01938-16.
(RXR)4XB TFA 是一种细胞穿透肽，可结合磷二酰胺吗啉寡聚体 (PMO)，形成肽结合的 PMO (PPMO)，并改善 PMO 向细菌细胞中的输送。(RXR)4XB TFA-PMO 偶合物可防止生物膜的形成，抑制Pseudomonas aeruginosa(MIC50为 0.5-16 μM)，并降低小鼠急性肺炎模型中的细菌负荷。