GlpBio

RVG Peptide (trifluoroacetate salt)

目录号: GC92117纯度: >98.00%同义词: Rabies Virus Glycoprotein; Rabies Virus Glycoprotein 29; RABV-G; RVG29
RVG Peptide (trifluoroacetate salt)是一种烟碱型乙酰胆碱受体（nAChR）拮抗剂（对人类受体的IC50=2.5μM）。
RVG Peptide (trifluoroacetate salt)
规格价格库存数量操作
1 mg¥686.00现货
1
5 mg¥2,408.00现货
1
10 mg¥3,780.00现货
1
25 mg¥7,714.00现货
1
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文献被引

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

Rabies virus glycoprotein (RVG) peptide is a nicotinic acetylcholine receptor (nAChR) antagonist (IC50 = 2.5 ?M for the human receptor).1 Lipid nanoparticles (LNPs) conjugated to RVG peptide selectively traffic to the brain over the lungs and liver in rats.2 LNPs conjugated to RVG peptide and encapsulating the iron chelator and prolyl hydroxylase inhibitor deferoxamine (DFO) reduce iron levels in the striatum and substantia nigra, as well as decrease levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and increase levels of superoxide dismutase (SOD) in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease. RVG-containing and DFO-encapsulating LNPs also increase the latency to fall in the rotarod test in the same model.

References:
[1]. Lentz, T.L., Hawrot, E., and Wilson, P.T.Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptorProteins2(4)298-307(1987).
[2]. You, L., Wang, J., Liu, T., et al.Correction to targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in Parkinsonian miceACS Nano16(11)19605(2022).

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

同义词
Rabies Virus Glycoprotein; Rabies Virus Glycoprotein 29; RABV-G; RVG29
化学名
L-tyrosyl-L-threonyl-L-isoleucyl-L-tryptophyl-L-methionyl-L-prolyl-L-α-glutamyl-L-asparaginyl-L-prolyl-L-arginyl-L-prolylglycyl-L-threonyl-L-prolyl-L-cysteinyl-L-α-aspartyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-arginylglycyl-L-lysyl-L-arginyl-L-alanyl-L-seryl-L-asparaginyl-glycine, trifluoroacetate salt
SMILES
O=C(N[C@]([C@H](O[H])C)([H])C(N[C@@](C(N[C@@H](CC1=CN([H])C2=C1C=CC=C2)C(N[C@@H](CCSC)C(N3CCC[C@H]3C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N[H])=O)C(N4CCC[C@H]4C(N[C@@H](CCC/N=C(N[H])/N)C(N5CCC[C@H]5C(NCC(N[C@]([C@H](O[H])C)([H])C(N6CCC[C@H]6C(N[C@@H](CS[H])C(N[C@@H](CC(O)=O)C(N[C@@](C(N[C@H](C(N[C@]([C@H](O[H])C)([H])C(N[C@@H](CC(N[H])=O)C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@@H](CC(N[H])=O)C(NCC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC8=CC=C(O[H])C=C8)N[H].FC(F)(C(O)=O)F
分子式
C141H217N43O43S2 ? XCF3COOH
分子量
3266.6 g/mol
溶解性
DMSO: Soluble: ≥10 mg/ml,PBS (pH 7.2): Soluble: ≥10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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g/mol