ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity[1].
ROS kinases-IN-1 (1-100 μM; 1 d) inhibits the growth of cervical cancer cell and glioblastoma cells[1].
Cell Viability Assay[1]
| Cell Line: | HeLa, U138, U87, LN18, and U118 cells |
| Concentration: | 1, 10, and 100 μM |
| Incubation Time: | one day |
| Result: | Showed EC50s for HeLa, U138, U87, LN18, and U118 cells of 20, 8, 8, 12, and 7 μM, respectively. |
[1]. Dorre A. GRUENEBERG, et al. Novel methods, compounds, and compositions for inhibition of ros. WO2014141129A2.