RIPK2 Inhibitor OD36 (hydrochloride)

RIPK2 inhibitor OD36 is an inhibitor of receptor-interacting serine/threonine kinase 2 (RIPK2; IC50 = 5.3 nM). It also inhibits wild-type and R206H mutant activin receptor-like kinase 2 (ALK2; IC50s = 47 and 22 nM, respectively). RIPK2 inhibitor OD36 (0.5 µM) inhibits activin A-induced chondrogenic and osteogenic differentiation in ATDC-5 cells overexpressing ALKR206H, an activating mutation found in patients with fibrodysplasia ossificans progressiva (FOP), which is characterized by progressive heterotopic ossification, or diffuse intrinsic pontine glioma (DIPG), a type of pediatric brain stem cancer. In vivo, RIPK2 inhibitor OD36 (6.25 mg/kg) reduces the number of peritoneal lavage neutrophils and lymphocytes in a mouse model of muramyl dipeptide-induced peritonitis.