Rink Amide Linker is a widely used linker in solid-phase peptide synthesis (SPPS). Rink Amide Linker is typically immobilized on a solid resin to anchor the growing peptide chain and is subsequently cleaved using 95% TFA to afford the peptide amide (–CONH₂)[1].
References:
[1] Rink H, Birr C. Synthesis of well-defined polystyrene Rink amide soluble supports and their use in peptide synthesis. Tetrahedron Letters. 1987;28(32):3787-3790.
Rink Amide Linker是一种在固相肽合成（SPPS）中广泛使用的连接臂。Rink Amide Linker通常固定在树脂上，用于锚定正在延伸的肽链，并最终通过95%的TFA裂解，释放出肽酰胺（–CONH₂）[1]。