GlpBio

Arenavirus

Arenavirus(沙粒病毒)

An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans.

Arenaviruses are a diverse family of small, enveloped, single-stranded RNA viruses which are generally propagated through asymptomatic, chronic infection of specific rodent hosts. Several arenaviruses are significant human pathogens, including five distinct hemorrhagic fever viruses designated category A by the CDC and NIAID, which is indicative of the level of highest threat to civilian populations. Several arenaviruses, including Lassa virus (LASV), are causative agents of hemorrhagic fever, for which effective therapeutic options are lacking.

The convergence of sensitivity to diverse small-molecule inhibitors thus identifies a robust new target for arenavirus antiviral discovery within the viral entry phase.

Arenavirus 相关产品(9)

  • GC18485 structure
    GC18485Retro-2
    CAS: 1429192-00-6
    纯度: >98.00%

    Retro-2是一种强效埃博拉病毒（EBOV）感染抑制剂，EC 50 值为12.2μM。

  • GC34252 structure
    GC34252GP(33-41)
    CAS: 161928-86-5

    GP(33-41)是一种由9个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒GP1抗原决定基中的最佳序列，能够上调RMA-S(DbKb)细胞表面H-2Db分子，SC50值为344nM。

  • GC34375 structure
    GC34375ST-193 hydrochloride
    CAS: 2320274-72-2
    纯度: >98.50%

    ST-193hydrochloride是有效广谱的arenavirus抑制剂；抑制Guanarito,Junin,Lassa和Machupo病毒的IC50值分别为0.44,0.62,1.4和3.1nM。

  • GC37681 structure
    GC37681ST-193
    CAS: 489416-12-8
    纯度: >99.50%

    ST-193是有效广谱的arenavirus抑制剂；抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。

  • GC37751 structure
    GC37751Tecovirimat
    CAS: 869572-92-9

    Tecovirimat (Arestvyr, SIGA-246, ST-246, TPOXX) is an antiviral that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs. Tecovirimat is developed for the treatment of smallpox infection.

  • GC65001 structure
    GC65001LHF-535
    CAS: 1450929-77-7
    纯度: >99.00%

    LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50 分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM，详细信息请参考专利文献 WO2012006552A1 中的化合物 1。

  • GC65488 structure
    GC65488GP(33-41) TFA
    纯度: >99.50%

    GP(33-41) TFA 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的最佳序列。GP(33-41) TFA 能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50 值为 344 nM。

  • GC69363 structure
    GC69363LCMV GP (61-80)
    CAS: 232598-19-5
    纯度: >98.00%

    LCMV GP (61-80) 是衍生自淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 糖蛋白 (GP) 的多肽片段，对应于 61-80 氨基酸序列。LCMV GP (61-80) 是一种特异性抗原决定簇，可以诱导 CD4+ T 细胞反应。

  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    纯度: >99.00%

    5,7-dihydroxychromone是一种从花生壳中提取的黄酮类分解产物，能抑制曼陀罗、玉米、花生和小麦胚根的伸长。