Imidazoline Receptors
Imidazoline Receptors(咪唑啉受体)
Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.
Imidazoline Receptors 相关产品(17)
- GC11198Moxonidine hydrochlorideCAS: 75536-04-8
An imidazoline I 1 and α 2A -adrenergic receptor agonist
- GC115882-BFI hydrochlorideCAS: 89196-95-2纯度: >98.00%
2-BFI hydrochloride是高亲和力、选择性的咪唑啉I2受体（I2R）激动剂，Ki值为70.1nM。
- GC15202BU 226 hydrochlorideCAS: 1186195-56-1
BU 226 hydrochloride 是一种选择性咪唑啉 2 (I2) 受体配体，对 I2 的 Ki 为 1.4 nM，对 I1 的 IC50 为 534.5 nM。
- GC15700BU 224 hydrochlorideCAS: 205437-64-5纯度: >98.00%
BU 224 hydrochloride 是一种选择性和高亲和力的咪唑啉 I2 受体配体，Ki 为 2.1 nM。
- GC63754Harmane-d1纯度: >95.00%
Harmane-d1 是 Harmane 的氘代物。Harmane，一种 β-咔啉生物碱 (BCA)，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。Harmane 对 I1 咪唑啉受体 (I1-Imidazoline receptor, IC50=30 nM) 的选择性是对 α2-肾上腺素受体 (IC50=18 μM) 的 1000 倍。Harmane 还是有效和选择性的单胺氧化酶抑制剂 (对 MAO A/B 的 IC50 值分别为 0.5 μM 和 5 μM)。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11198 | Moxonidine hydrochloride | 75536-04-8 | - | |
An imidazoline I 1 and α 2A -adrenergic receptor agonist | ||||
| GC11580 | BU 239 hydrochloride | 1217041-98-9 | - | |
Imidazoline receptors-selective antagonist | ||||
| GC11588 | 2-BFI hydrochloride | 89196-95-2 | >98.00% | |
2-BFI hydrochloride是高亲和力、选择性的咪唑啉I2受体（I2R）激动剂，Ki值为70.1nM。 | ||||
| GC12629 | Moxonidine | 75438-57-2 | >98.00% | |
An imidazoline I 1 and α 2A -adrenergic receptor agonist | ||||
| GC13017 | Rilmenidine Phosphate | 85409-38-7 | >98.00% | |
An antihypertensive agent | ||||
| GC14934 | AGN 192403 hydrochloride | 1021868-90-5 | >98.00% | |
I1 imidazoline receptor | ||||
| GC14958 | RS 45041-190 hydrochloride | 204274-74-8 | - | |
Highly selective I2 imidazoline receptor ligand | ||||
| GC15202 | BU 226 hydrochloride | 1186195-56-1 | - | |
BU 226 hydrochloride 是一种选择性咪唑啉 2 (I2) 受体配体，对 I2 的 Ki 为 1.4 nM，对 I1 的 IC50 为 534.5 nM。 | ||||
| GC15384 | Harmane | 486-84-0 | >99.50% | |
A β-carboline with diverse biological activities | ||||
| GC15700 | BU 224 hydrochloride | 205437-64-5 | >98.00% | |
BU 224 hydrochloride 是一种选择性和高亲和力的咪唑啉 I2 受体配体，Ki 为 2.1 nM。 | ||||
| GC16831 | Agmatine sulfate | 2482-00-0 | >98.00% | |
A polyamine metabolite | ||||
| GC31094 | CR4056 | 1004997-71-0 | - | |
CR4056是一个选择性的人重组MAO-A抑制剂，其IC50值为202.7nM。CR4056也是咪唑啉-2受体(I2R)的配体，其IC50值为596nM。 | ||||
| GC60325 | Rilmenidine | 54187-04-1 | - | |
An antihypertensive agent | ||||
| GC63754 | Harmane-d1 | - | >95.00% | |
Harmane-d1 是 Harmane 的氘代物。Harmane，一种 β-咔啉生物碱 (BCA)，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。Harmane 对 I1 咪唑啉受体 (I1-Imidazoline receptor, IC50=30 nM) 的选择性是对 α2-肾上腺素受体 (IC50=18 μM) 的 1000 倍。Harmane 还是有效和选择性的单胺氧化酶抑制剂 (对 MAO A/B 的 IC50 值分别为 0.5 μM 和 5 μM)。 | ||||
| GC69206 | Harmane-d | - | >98.00% | |
Harmane-d 是 Harmane 的氘代物。Harmane，一种 β-咔啉生物碱 (BCA)，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。Harmane 对 I1 咪唑啉受体 (I1-Imidazoline receptor, IC50=30 nM) 的选择性是对 α2-肾上腺素受体 (IC50=18 μM) 的 1000 倍。Harmane 还是有效和选择性的单胺氧化酶抑制剂 (对 MAO A/B 的 IC50 值分别为 0.5 μM 和 5 μM)。 | ||||
| GC74240 | Allantoin-13C2,15N4 | 1219402-51-3 | >99.00% | |
Allantoin-13C2,15N4是13C和15N标记的尿囊素。 | ||||
| GN10492 | Allantoin | 97-59-6 | >99.50% | |
A product of purine and uric acid metabolism | ||||