GlpBio

TLR

TLR(Toll样受体)

TLR (Toll-like receptor) is a family of receptors that expressed on immune cells including B lymphoctes, macrophages and mast cells. Ir identifies pathogen-associated molecular patterns and mediate the cytokines productions for activation of innate immunity.

TLR 相关产品(139)

  • GC18761 structure
    GC18761FSL-1
    CAS: 322455-70-9

    FSL-1是一种合成的二酰基脂肽TLR2/6激动剂。

  • GC19357 structure
    GC19357TLR7-agonist-1
    CAS: 1642857-69-9
    纯度: >99.00%

    A TLR7 agonist

  • GC25314 structure
    GC25314CU-CPD107
    CAS: 2573912-32-8
    纯度: >98.50%

    CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands.

  • GC30516 structure
    GC30516TLR7/8 agonist 1 dihydrochloride
    CAS: 1620278-72-9
    纯度: >98.00%

    A dual agonist of TLR7 and TLR8

  • GC31729 structure
    GC31729CU-CPT-9b (TLR8-specific antagonist 1)
    CAS: 2162962-69-6
    纯度: >98.00%

    A TLR8 antagonist

  • GC31745 structure
    GC31745CU-CPT-9a
    CAS: 2165340-32-7
    纯度: >99.50%

    A TLR8 antagonist

  • GC31776 structure
    GC31776MD2-IN-1
    CAS: 111797-22-9
    纯度: >99.50%

    MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189?μM.

  • GC31792 structure
    GC31792PF-4878691 (3M-852A)
    CAS: 532959-63-0
    纯度: >98.50%

    PF-4878691 (3M-852A) (3M-852A) 是一种有效的、具有口服活性的选择性 Toll 样受体 7 (TLR7) 激动剂，模拟其抗病毒和炎症活性。

  • GC32057 structure
    GC32057AN-3485
    CAS: 1213827-99-6
    纯度: >98.50%

    AN-3485是一种benzoxaborole类似物,Toll样受体Toll-LikeReceptors(TLRs)抑制剂,IC50范围为18~580nM。

  • GC33076 structure
    GC33076Telratolimod (MEDI 9197)
    CAS: 1359993-59-1
    纯度: >99.00%

    Telratolimod (MEDI 9197)是一种有效的toll-like receptor 7（TLR-7）和toll-like receptor 8（TLR-8）的激动剂。

  • GC33405 structure
    GC33405Neoseptin 3
    CAS: 1622863-21-1
    纯度: >98.00% / >99.50%

    Neoseptin3是Toll样受体4/髓样分化因子2(mTLR4/MD-2)的激动剂，其EC50值为18.5μM。

  • GC33820 structure
    GC33820C29
    CAS: 363600-92-4
    纯度: >98.00%

    C29 是一种 Toll 样受体 2 (TLR2) 抑制剂。

  • GC33828 structure
    GC33828E6446 dihydrochloride (E-6446 dihydrochloride)
    CAS: 1345675-25-3
    纯度: >99.50%

    E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor.

  • GC33834 structure
    GC33834CU-CPT17e
    CAS: 2109805-75-4
    纯度: >98.00%

    CU-CPT17e是一种多Toll样受体(TLR)激动剂，可激活TLR3，TLR8和TLR9。

  • GC33900 structure
    GC33900E6446
    CAS: 1219925-73-1

    E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro.

  • GC33910 structure
    GC33910Gardiquimod trifluoroacetate
    CAS: 1159840-61-5
    纯度: >99.50%

    A selective agonist of human TLR7

  • GC36578 structure
    GC36578MD2-TLR4-IN-1
    CAS: 2249801-12-3
    纯度: >99.50%

    MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively.

  • GC36794 structure
    GC36794Okanin
    CAS: 484-76-4
    纯度: >98.00%

    Okanin 是 Coreopsis tinctoria 的有效成分。Okanin 通过抑制 TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。

  • GC38728 structure
    GC387281V209
    CAS: 1062444-54-5
    纯度: >99.50%

    1V209 (T7, TLR7 agonist T7) is an agonist of Toll-like receptor 7 (TLR7) with anti-tumor effects. 1V209 can be used as vaccine adjuvants, enhances antigen specific humoral and cellular immune responses.

  • GC38907 structure
    GC38907DSR-6434
    CAS: 1059070-10-8
    纯度: >99.00%

    A TLR7 agonist

  • GC39134 structure
    GC39134Isofraxidin
    CAS: 486-21-5
    纯度: >98.00%

    Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.

  • GC39285 structure
    GC39285CU-T12-9
    CAS: 1821387-73-8
    纯度: >98.00% / >99.00%

    CU-T12-9是一种特异性Toll样受体TLR1/TLR2异二聚体的小分子激动剂，其EC 50 为52.9nM，CU-T12-9通过促进TLR1和TLR2二聚化，进而激活NF-κB信号通路

  • GC39372 structure
    GC39372Desethyl chloroquine diphosphate
    CAS: 247912-76-1
    纯度: >99.00%

    Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。

  • GC47127 structure
    GC47127CU-115
    CAS: 2471982-20-2
    纯度: >98.00%

    A TLR8 antagonist