Cyclic GMP-AMP Synthase

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0?nM and 442?nM for h-cGAS and m-cGAS, respectively.

cGAS-IN-2（化合物109）是环GMP-AMP合酶（cGAS）的强效抑制剂，对h-cGAS的IC50为0.01512μM。