GlpBio

Complement System

Complement System(补体系统)

The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system. Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.

Complement System 相关产品(57)

  • GC10449 structure
    GC10449PMX 205
    CAS: 514814-49-4

    A potent antagonist of C5aR

  • GC11800 structure
    GC11800SB 290157 (trifluoroacetate salt)
    CAS: 1140525-25-2
    纯度: >99.50%

    SB 290157（三氟乙酸盐）用作选择性非肽类 C3aR 拮抗剂。

  • GC12342 structure
    GC12342NDT 9513727
    CAS: 439571-48-9
    纯度: >99.00%

    A competitive antagonist of the C5a receptor

  • GC15251 structure
    GC15251Compstatin
    CAS: 206645-99-0

    A peptide inhibitor of complement activation

  • GC17129 structure
    GC17129W 54011
    CAS: 405098-33-1
    纯度: >98.00%

    A selective C5aR antagonist

  • GC17263 structure
    GC17263Leukadherin 1
    CAS: 344897-95-6
    纯度: >98.00%

    An allosteric activator of CD11b/CD18

  • GC17510 structure
    GC17510Compstatin control peptide
    CAS: 301544-78-5

    Compstatin 对照肽是 Compstatin 的阴性对照。

  • GC19043 structure
    GC19043Avacopan
    CAS: 1346623-17-3

    A C5a 1 receptor antagonist

  • GC31928 structure
    GC31928C3a 70-77 (Complement 3a (70-77))
    CAS: 63555-63-5

    C3a 70-77 (Complement 3a (70-77)) 是一种对应于 C3a 的 COOH 末端的八肽，具有 C3a 的特异性和 1% 至 2% 的生物活性。

  • GC34434 structure
    GC34434PMX 205 Trifluoroacetate
    纯度: >98.00%

    A potent antagonist of C5aR

  • GC35481 structure
    GC35481BCX 1470
    CAS: 217099-43-9

    BCX 1470能抑制factor D和C1s的酯水解活性，IC50分别为96 nM和1.6 nM。

  • GC35482 structure
    GC35482BCX 1470 methanesulfonate
    CAS: 217099-44-0
    纯度: >99.50%

    BCX 1470 methanesulfonate 能抑制factor D和C1s的酯水解活性，IC50分别为96 nM和1.6 nM。

  • GC35575 structure
    GC35575C3a (70-77) TFA

    C3a (70-77) TFA (Complement 3a (70-77) TFA) 是对应于 C3a 的 COOH 末端的八肽，表现出 C3a 的特异性和 1 至 2％ 的生物活性。

  • GC35724 structure
    GC35724Complement C5-IN-1
    CAS: 2365402-67-9
    纯度: >98.00%

    Compound C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。Compound C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50％人全血 MAC 沉积的 IC50 值为 0.77 μM。

  • GC36035 structure
    GC36035FD-IN-1
    CAS: 1646682-14-5
    纯度: >99.50%

    FD-IN-1 (Compound 12) 是一种补体因子 D (FD) 抑制剂，IC50 为 12 nM。补体因子 D 是一种高特异性的 S1 丝氨酸蛋白酶，在先天免疫系统的替代补体途径中起着重要作用。FD-IN-1 还抑制因子 XIa (FXIa) 和类胰蛋白酶 β2，IC50 分别为 7.7 和 6.5 μM。

  • GC36472 structure
    GC36472LNP023
    CAS: 1644670-37-0
    纯度: >99.50%

    LNP023 (LNP023) 是一流的、具有口服生物利用度的、高效和高选择性的因子 B 抑制剂，IC50 值为 10 nM。

  • GC38162 structure
    GC38162Danicopan
    CAS: 1903768-17-1
    纯度: >99.50%

    A Factor D inhibitor

  • GC38880 structure
    GC38880(Z)-Leukadherin-1
    CAS: 2055362-72-4
    纯度: >98.00%

    (Z)-Leukadherin-1 (ADH-503 free base) 是一种具有口服活性的，变构的 CD11b 激动剂。(Z)-Leukadherin-1 可以导致与肿瘤相关的巨噬细胞重新极化，减少肿瘤浸润性免疫抑制骨髓细胞的数量，并增强树突状细胞的反应。

  • GC40775 structure
    GC40775Dexamethasone
    CAS: 50-02-2
    纯度: >98.00% / >99.00%

    地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。

  • GC50176 structure
    GC50176PMX 53
    CAS: 219639-75-5
    纯度: >98.00% / >99.50%

    PMX 53是一种高效且具有细胞渗透性和口服活性的C5a受体（CD88）拮抗剂，IC 50 值为20nM。

  • GC50238 structure
    GC50238PMX 53c

    Negative control for PMX 53

  • GC60040 structure
    GC60040ADH-503
    CAS: 2055362-74-6
    纯度: >95.00%

    ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b.

  • GC60149 structure
    GC60149EG01377 dihydrochloride
    纯度: >98.00%

    EG01377dihydrochloride是有效的、可生物利用的和选择性的neuropilin-1(NRP1)抑制剂，Kd值为1.32μM，对NRP1-a1和NRP1-b1的IC50值均为609nM。EG01377dihydrochloride具有抗血管生成，抗迁移及抗肿瘤等活性。

  • GC61335 structure
    GC61335TLQP-21 TFA
    纯度: >99.00%

    TLQP-21TFA是VGF衍生的具有内分泌和内分泌特性的肽，是一种强效的G蛋白偶联受体补体3a受体1(C3aR1)激动剂(EC50:小鼠TLQP-21=10.3μM；人TLQP-21=68.8μM)。TLQP-21TFA激活C3aR1，从而诱导细胞内Ca2+的增加。TLQP-21TFA可用于研究调节伤害感受和其他相关生理功能。