GlpBio

CD73

CD73 (Ecto-5′-nucleotidase), a component of the purinergic signaling pathway, is a 70-kD glycosylphosphatidylinositol-anchored cell surface protein encoded by the NT5E gene.

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape. CD73 plays a crucial role in switching on adenosinergic signaling. CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other.

Overexpression of CD73 is associated with resistance to antitumor agents. Knockdown of CD73 inhibits in vitro cell growth, cell cycle progression and cell migration in many cancers. CD73 and its associated pathways may be useful as therapeutic targets.

CD73 相关产品(14)

  • GC31914 structure
    GC31914CD73-IN-1
    CAS: 2132396-40-6
    纯度: >98.50%

    An inhibitor of CD73

  • GC32795 structure
    GC32795PSB-12379
    CAS: 1802226-78-3
    纯度: >99.50%

    An inhibitor of CD73

  • GC36587 structure
    GC36587MethADP
    CAS: 3768-14-7

    MethADP 是一个特异性的 CD73 抑制剂。

  • GC36588 structure
    GC36588MethADP sodium salt
    CAS: 89016-30-8

    MethADP (sodium salt) 是一个特异性的 CD73 抑制剂。

  • GC62331 structure
    GC62331CD73-IN-3
    CAS: 2375815-63-5
    纯度: >99.50%

    LY-3475070 is a potent, selective and orally bioavailable inhibitor of the ectoenzyme CD73 (cluster of differentiation 73, 5'-ecto-nucleotidase, 5'-NT, ecto-5'-nucleotidase).

  • GC62452 structure
    GC62452CD73-IN-4
    CAS: 2216764-29-1
    纯度: >99.50%

    CD73-IN-4 是一种高效、选择性的亚甲基膦酸 CD73 抑制剂，对人 CD73 作用的 IC50 值为 2.6 nM。CD73-IN-4 在癌症免疫学研究中具有潜在的应用价值。

  • GC62694 structure
    GC62694OP-5244
    CAS: 2381268-71-7
    纯度: >99.50%

    OP-5244 是一种有效和具有口服活性的 CD73 抑制剂，IC50 值为 0.25 nM。OP-5244 通过阻断腺苷的产生来逆转免疫抑制作用，具有进行癌症研究的潜力。

  • GC62695 structure
    GC62695OP-5244 sodium

    OP-5244 sodium 是一种有效和具有口服活性的 CD73 抑制剂，IC50 值为 0.25 nM。OP-5244 sodium 通过阻断腺苷的产生来逆转免疫抑制作用，具有进行癌症研究的潜力。

  • GC65293 structure
    GC65293AB-680
    CAS: 2105904-82-1
    纯度: >98.00%

    AB-680 是一种有效、可逆、选择性的 CD73 (胞外核苷酸酶) 抑制剂，对 hCD73 的 Ki 值为 4.9 pM，对其选择性是对相关胞外核苷酸酶 CD39 的 10000 多倍。具有抗肿瘤活性。

  • GC65470 structure
    GC65470Oleclumab
    CAS: 1803176-05-7
    纯度: >98.00%

    Oleclumab (MEDI9447) 是一种人 IgG1Λ 抗 CD73 单克隆抗体，可抑制 CD73 功能。Oleclumab 具有抗肿瘤活性。

  • GC68344 structure
    GC68344Mupadolimab
    CAS: 2451856-97-4

    Mupadolimab (CPI-006) 是一种 IgG1κ 人源化的 FcγR 结合缺陷抗 CD73 单抗，激活 CD73POS B 细胞。

  • GC68346 structure
    GC68346Uliledlimab
    CAS: 2378407-27-1

    Uliledlimab 是一种有效的抗 CD73 人源单克隆抗体。Uliledlimab 抑制胞外单磷酸腺苷 (AMP) 向腺苷的转化。Uliledlimab 可用于癌症的研究。

  • GC68386 structure
    GC68386CD73-IN-5
    CAS: 2412019-99-7

    CD73-IN-5 是一种有效且选择性的非核苷酸小分子 CD73 抑制剂（IC50 = 19 nM）。

  • GC69453 structure
    GC69453MethADP triammonium
    纯度: >99.00%

    MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium 是一种 CD73 抑制剂。MethADP 可用于 ATP-腺苷通路的研究。