GlpBio

Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

研究方向

Apoptosis 相关产品(777)

  • GC61252 structure
    GC61252Rotundifuran
    CAS: 50656-65-0

    Rotundifuran是一种从Vitexrotundifolia中分离的拉丹烷型二萜。Rotundifuran能够抑制人骨髓白血病细胞的细胞周期进程并诱导细胞凋亡。

  • GC61264 structure
    GC61264Sandacanol
    CAS: 28219-61-6

    Sandacanol是嗅觉受体(OR10H1)的特异性激动剂。Sandacanol诱导膀胱癌细胞发生细胞周期停滞和凋亡(apoptosis)。

  • GC61314 structure
    GC61314Taltobulin hydrochloride
    纯度: >99.00%

    Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物，Taltobulin是一种有效的抗微管剂(antimicrotubule)，可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡(apoptosis)。

  • GC61349 structure
    GC61349Tributyrin
    CAS: 60-01-5
    纯度: >98.00%

    Glycerol tributyrate (Tributyrin) is a triglyceride that may inhibit cell growth and induce cell differentiation.

  • GC61352 structure
    GC61352Triglycidyl isocyanurate
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    纯度: >98.00%

    Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.

  • GC61361 structure
    GC61361Tubuloside B
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    TubulosideB是可从Cistanchesalsa茎中分离出的天然产物，可抑制TNFα诱导的细胞凋亡。TubulosideB还具有抗氧化活性。

  • GC61382 structure
    GC61382Xanthoangelol
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    纯度: >98.00%

    Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.

  • GC61392 structure
    GC61392ZZW-115
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    A NUPR1 inhibitor

  • GC61393 structure
    GC61393ZZW-115 hydrochloride
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    纯度: >98.00%

    A NUPR1 inhibitor

  • GC61414 structure
    GC61414ICCB280
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    纯度: >98.00%

    ICCB280是一种有效的C/EBPα诱导剂。ICCB280通过激活C/EBPα并影响其下游靶点(例如C/EBPε，G-CSFR和c-Myc)，具有抗白血病特性，包括终末分化，增殖停滞和凋亡。

  • GC61436 structure
    GC61436Gallic acid hydrate
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    纯度: >98.00%

    A phenol with diverse biological activities

  • GC61437 structure
    GC61437(E)-Methyl 4-coumarate
    CAS: 19367-38-5
    纯度: >98.00%

    A phenol with diverse biological activities

  • GC61466 structure
    GC61466DMU-212
    CAS: 134029-62-2
    纯度: >99.50%

    DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein.

  • GC61492 structure
    GC61492SW106065
    CAS: 62289-81-0
    纯度: >99.50%

    SW-106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST), which can inhibit ATP consumption of sporadic MPNST and other models of MPNST with an EC50 of 1 ?M.

  • GC61524 structure
    GC61524SC-43
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    纯度: >98.00%

    An SHP-1 activator

  • GC61532 structure
    GC61532CCI-007
    CAS: 939228-52-1
    纯度: >98.00%

    CCI-007 is a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.

  • GC61552 structure
    GC61552PAO-Nap
    CAS: 1613402-20-2

    PAO-Nap是NAP(naphthalimide)荧光基团修饰的PAO。PAO通过选择性靶向硫氧蛋白还原酶诱导HL-60细胞氧化应激介导的凋亡。

  • GC61567 structure
    GC61567CMLD-2
    CAS: 958843-91-9
    纯度: >98.00%

    CMLD-2是一种HuR-ARE相互作用的抑制剂。CMLD-2竞争性结合HuR蛋白，破坏其与富含腺嘌呤-尿苷元素(ARE)的mRNA靶标的相互作用(Ki=350nM)。CMLD-2可诱导凋亡并在结肠癌，胰腺癌，甲状腺癌和肺癌细胞系中表现出抗肿瘤活性。Hu抗原R(HuR)是一种RNA结合蛋白，可以调节靶标mRNA的稳定性和翻译。

  • GC61608 structure
    GC61608HLI373 dihydrochloride
    CAS: 1782531-99-0

    HLI373dihydrochloride是一种有效的Hdm2抑制剂。HLI373抑制Hdm2泛素连接酶活性。HLI373dihydrochloride可有效诱导肿瘤细胞(对DNA破坏剂敏感的)凋亡(apoptosis)。具有抗疟疾(antimalarial)活性。

  • GC61623 structure
    GC61623NAE-IN-M22
    CAS: 864420-54-2
    纯度: >99.50%

    NEDD8 inhibitor M22 (NAE-IN-M22) is a novel selective NEDD8 activating enzyme (NAE) inhibitor with GI50 of 5.5 μM in A549 cells.

  • GC61628 structure
    GC61628Neriifolin
    CAS: 466-07-9
    纯度: >96.00%

    Neriifolin是一种穿透中枢神经系统的强心苷，是一种Na+,K+-ATPase的抑制剂。Neriifolin可靶向beclin1，抑制LC3相关吞噬体的形成，改善实验性自身免疫性脑脊髓炎(EAE)的发展。Neriifolin诱导人肝癌HepG2细胞周期阻滞和凋亡。

  • GC61665 structure
    GC61665Tetrahydroxyquinone monohydrate
    CAS: 1215458-51-7
    纯度: >97.00%

    A redox-active hydroxyquinone

  • GC61669 structure
    GC61669Ethyl 3,4-dihydroxybenzoate
    CAS: 3943-89-3
    纯度: >99.00%

    Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂，是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂，具有骨骼保护作用。

  • GC61750 structure
    GC61750(Rac)-Indoximod
    CAS: 26988-72-7
    纯度: >97.00%

    (Rac)-Indoximod(1-Methyl-DL-tryptophan)是吲哚胺-2,3-双加氧酶(IDO)抑制剂。(Rac)-Indoximod和IFN-γ联用显著降低了表达α-SMA的人心肌成纤维细胞活性，并通过上调IRF-1，Fas和FasL基因诱导凋亡(apoptosis)。