Nicotinic Receptor
Nicotinic Receptor(烟碱受体)
Nicotinic acetylcholine receptors is a family of ligand-gated ion channels that plays a significant role in the synaptic signaling and involved in neurological diseases, such as Alzheimer’s, Parkinson’s and schizophrenia etc.
Nicotinic Receptor 相关产品(62)
- GC12952PNU 282987CAS: 123464-89-1纯度: >99.50%
PNU 282987是一种选择性α7烟碱乙酰胆碱受体（α7nAChR）激动剂，与抗炎途径相关，也是5-HT3受体的拮抗剂，PNU 282987对α7nAChR的EC 50 为154nM （K i α7nAChR=27nM，大鼠脑匀浆），对5-HT3受体的IC 50 为4541nM （K i 5-HT3R=1662nM, GR-65630）。
- GC13118Dihydro-β-erythroidine hydrobromideCAS: 29734-68-7纯度: >98.50%
Dihydro-β-erythroidine (DHβE) hydrobromide 是一种有效的、具有口服活性的竞争性神经元 nAChR 拮抗剂。
- GC13644α-Conotoxin EICAS: 170663-33-9
Selective antagonist of neuromuscular nicotinic receptors α1β1γδ
- GC13678Methyllycaconitine citrateCAS: 112825-05-5; 351344-10-0纯度: >98.00% / >99.00%
Methyllycaconitine citrate (MLA)，一种从飞燕草种子中分离出来的降二萜类生物碱。
- GC14157(-)-Lobeline hydrochlorideCAS: 134-63-4纯度: >99.50%
An alkaloid with diverse biological activities
- GC142255-Iodo-A-85380, 5-trimethylstannyl N-BOC derivativeCAS: 213766-21-3
Precursor to ligand for the α4β2 nicotinic receptor
- GC14296α-Conotoxin PIACAS: 669050-68-4
α-Conotoxin PIA 是一种烟碱型乙酰胆碱受体 (nAChR) 拮抗剂，靶向含有 α6 和 α3 亚基的 nAChR 亚型。
- GC15146PHA 543613 hydrochlorideCAS: 478149-53-0
PHA 543613 hydrochloride 是一种有效的、口服活性的、脑渗透性和选择性的 α7 nAChR 激动剂，Ki 为 8.8 nM。
- GC15703Chlorisondamine diiodideCAS: 96750-66-2
A long-lasting antagonist of nAChRs and ganglion blocker
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC12952 | PNU 282987 | 123464-89-1 | >99.50% | |
PNU 282987是一种选择性α7烟碱乙酰胆碱受体（α7nAChR）激动剂，与抗炎途径相关，也是5-HT3受体的拮抗剂，PNU 282987对α7nAChR的EC 50 为154nM （K i α7nAChR=27nM，大鼠脑匀浆），对5-HT3受体的IC 50 为4541nM （K i 5-HT3R=1662nM, GR-65630）。 | ||||
| GC12959 | SIB 1553A hydrochloride | 191611-89-9 | >99.00% | |
A β4 subunit-selective nAChR agonist | ||||
| GC13052 | SR 16584 | 1150153-86-8 | - | |
Selective antagonist of α3β4 nicotinic acetylcholine receptors | ||||
| GC13064 | NS 1738 | 501684-93-1 | >98.00% | |
A positive allosteric modulator of α7-containing nAChRs | ||||
| GC13118 | Dihydro-β-erythroidine hydrobromide | 29734-68-7 | >98.50% | |
Dihydro-β-erythroidine (DHβE) hydrobromide 是一种有效的、具有口服活性的竞争性神经元 nAChR 拮抗剂。 | ||||
| GC13346 | TQS | 353483-92-8 | >99.00% | |
TQS 是一种 α7 烟碱型乙酰胆碱受体 (nAChR) 正变构调节剂。 | ||||
| GC13366 | MG 624 | 77257-42-2 | - | |
An antagonist of neuronal nicotinic AChRs | ||||
| GC13644 | α-Conotoxin EI | 170663-33-9 | - | |
Selective antagonist of neuromuscular nicotinic receptors α1β1γδ | ||||
| GC13678 | Methyllycaconitine citrate | 112825-05-5; 351344-10-0 | >98.00% / >99.00% | |
Methyllycaconitine citrate (MLA)，一种从飞燕草种子中分离出来的降二萜类生物碱。 | ||||
| GC14157 | (-)-Lobeline hydrochloride | 134-63-4 | >99.50% | |
An alkaloid with diverse biological activities | ||||
| GC14225 | 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative | 213766-21-3 | - | |
Precursor to ligand for the α4β2 nicotinic receptor | ||||
| GC14296 | α-Conotoxin PIA | 669050-68-4 | - | |
α-Conotoxin PIA 是一种烟碱型乙酰胆碱受体 (nAChR) 拮抗剂，靶向含有 α6 和 α3 亚基的 nAChR 亚型。 | ||||
| GC14342 | Sazetidine A dihydrochloride | 1197329-42-2 | - | |
α4β2 nicotinic acetylcholine receptor ligand | ||||
| GC14353 | α-Conotoxin ImI | 156467-85-5 | - | |
A conotoxin and an antagonist of α7 nAChRs | ||||
| GC14410 | (±)-Epibatidine | 148152-66-3 | - | |
An agonist of α4β2 subunit-containing nAChRs | ||||
| GC14588 | Myosmine | 532-12-7 | >99.50% | |
A minor tobacco alkaloid | ||||
| GC15132 | TC 1698 dihydrochloride | 700834-58-8 | - | |
nicotinic α7 receptor agonist | ||||
| GC15141 | ACV 1 | 740980-24-9 | - | |
Neuronal nicotinic receptor antagonist | ||||
| GC15146 | PHA 543613 hydrochloride | 478149-53-0 | - | |
PHA 543613 hydrochloride 是一种有效的、口服活性的、脑渗透性和选择性的 α7 nAChR 激动剂，Ki 为 8.8 nM。 | ||||
| GC15160 | TC 2559 difumarate | 212332-35-9 | - | |
A partial agonist for α4β2 subunit-containing nAChRs | ||||
| GC15333 | A 844606 | 861119-08-6 | - | |
α7 nAChR partial agonist | ||||
| GC15383 | 4-Acetyl-1,1-dimethylpiperazinium iodide | 75667-84-4 | - | |
nicotinic agonist | ||||
| GC15703 | Chlorisondamine diiodide | 96750-66-2 | - | |
A long-lasting antagonist of nAChRs and ganglion blocker | ||||
| GC15910 | S 24795 | 304679-75-2 | - | |
S 24795 是 α7 nAChR 的部分激动剂，可改善老年小鼠的记忆功能，用于治疗与衰老相关的记忆障碍。 | ||||